{"id":"W4206137796","doi":"10.1371/journal.pone.0261987","title":"MHC class I antigen cross-presentation mediated by PapMV nanoparticles in human antigen-presenting cells is dependent on autophagy","year":2021,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec; Université de Montréal; Institute for Research in Immunology and Cancer; Centre Hospitalier de l’Université de Montréal","funders":"Institute of Cancer Research; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Cross-presentation; Antigen presentation; MHC class I; Antigen processing; Transporter associated with antigen processing; Cytotoxic T cell; Major histocompatibility complex; Epitope; Antigen; Biology; Cell biology; Autophagy; Immune system; T cell; Immunology; Biochemistry; Apoptosis; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137136,0.0001495783,0.000197571,0.00006900697,0.0001122756,0.0002334237,0.0000714819,0.0002099101,0.0005870442],"category_scores_gemma":[0.0000990279,0.00009115393,0.0001984258,0.00005420654,0.0001276907,0.0001486876,0.0001291795,0.0002338674,0.0002185488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001802937,"about_ca_system_score_gemma":0.0001314425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000233358,"about_ca_topic_score_gemma":0.0002384353,"domain_scores_codex":[0.9999152,0.00001861744,0.00000678653,0.00002048481,0.00001738328,0.00002141024],"domain_scores_gemma":[0.9999477,0.00001799893,0.00001135724,0.000007089509,0.000008651534,0.00000719923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000741226,0.00001358914,0.0001194095,0.00002945847,0.000003317414,0.00005085591,0.0000145022,0.00004597551,0.9985899,0.00008974481,0.000028928,0.0009400384],"study_design_scores_gemma":[0.000008844057,0.0001718229,0.002148913,0.000005227681,0.000007708526,0.0002770014,0.0000157097,0.0007765608,0.9957446,0.00005933773,0.0007812085,0.000002984453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950015,0.001195949,0.002303377,0.00005722461,0.00002042587,0.000017297,0.00006956862,0.00004138789,0.001293203],"genre_scores_gemma":[0.9973848,0.000409157,0.001142906,0.00003552136,0.000005960306,0.00001636377,0.00008680457,0.000008767904,0.0009096802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005870442,"threshold_uncertainty_score":0.001963854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03907921450914158,"score_gpt":0.2951031008902392,"score_spread":0.2560238863810976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}