{"id":"W4206155884","doi":"10.1016/j.cellsig.2021.110239","title":"Biosensor-based profiling to track cellular signalling in patient-derived models of dilated cardiomyopathy","year":2022,"lang":"en","type":"review","venue":"Cellular Signalling","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Induced pluripotent stem cell; Signalling; Computational biology; Dilated cardiomyopathy; Disease; Paracrine signalling; Signalling pathways; Context (archaeology); Neuroscience; Biology; Medicine; Bioinformatics; Signal transduction; Cell biology; Receptor; Pathology; Heart failure; Internal medicine; Genetics; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001389199,0.001235724,0.005626521,0.001530258,0.0002584292,0.00005007281,0.0004674366,0.0005786341,0.0001009136],"category_scores_gemma":[0.0001924862,0.001203226,0.002397969,0.002105432,0.0001281624,0.0001078192,0.0003369563,0.001494587,0.00002425326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005945105,"about_ca_system_score_gemma":0.0007907221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005623447,"about_ca_topic_score_gemma":0.000001740578,"domain_scores_codex":[0.9929069,0.0006962177,0.00253908,0.001540891,0.001240031,0.001076846],"domain_scores_gemma":[0.9968918,0.00060227,0.0009102095,0.0009207343,0.0002814915,0.0003934896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008533144,0.001306622,0.0000394012,0.07522807,0.003032728,0.009274221,0.004133292,0.1004793,0.3354326,0.0001580023,0.00005950067,0.4700029],"study_design_scores_gemma":[0.004696135,0.002304584,0.000001054791,0.07003243,0.01067512,0.0002014686,0.002753939,0.0130749,0.2753406,0.0001173907,0.6159888,0.004813638],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0190077,0.9651613,0.009984381,0.00001358154,0.0005521075,0.004299754,0.0001613136,0.0001874386,0.0006323857],"genre_scores_gemma":[0.1208541,0.873545,0.003114668,0.00008509313,0.0003570256,0.0006751891,0.0009454178,0.0003779854,0.00004551073],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6159293,"threshold_uncertainty_score":0.9990417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06848909929327895,"score_gpt":0.2845343958926961,"score_spread":0.2160452965994171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}