{"id":"W4206174687","doi":"10.1182/blood.v124.21.lba-5.lba-5","title":"A Randomized Phase II Study of Azacitidine Combined with Lenalidomide or with Vorinostat Vs. Azacitidine Monotherapy in Higher-Risk Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML): North American Intergroup Study SWOG S1117","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Lenalidomide; Azacitidine; Internal medicine; Chronic myelomonocytic leukemia; International Prognostic Scoring System; Decitabine; Oncology; Myelodysplastic syndromes; Hypomethylating agent; Phases of clinical research; Clinical endpoint; Adverse effect; Gastroenterology; Randomized controlled trial; Clinical trial; Bone marrow; Multiple myeloma; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001336318,0.000924379,0.003617464,0.0009448475,0.0002321571,0.00007106944,0.0004695561,0.00009761925,0.00009352514],"category_scores_gemma":[0.0004064601,0.0005817462,0.000139505,0.001780405,0.001019856,0.0002479875,0.0002700801,0.001006394,0.000007142909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006603199,"about_ca_system_score_gemma":0.0009254531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00274487,"about_ca_topic_score_gemma":0.009638529,"domain_scores_codex":[0.9939864,0.001227389,0.001384059,0.001266054,0.001118298,0.001017839],"domain_scores_gemma":[0.9955356,0.001668349,0.0008004152,0.001193219,0.0003030401,0.0004994258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.742421,0.01831362,0.2166767,0.0004284438,0.005084583,0.001977055,0.005739082,0.0002989603,0.0008217908,0.00001865944,0.00004066823,0.008179489],"study_design_scores_gemma":[0.7640464,0.1629837,0.06237685,0.0004295537,0.002417596,0.0003003557,0.001893654,0.003973974,0.0009037783,0.000006266589,0.00003427633,0.0006335187],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99158,0.0001745331,0.0003086677,0.0001932779,0.00004971179,0.007431321,0.00003301247,0.0001509369,0.00007855883],"genre_scores_gemma":[0.997051,0.0004100291,0.0005122493,0.00008060778,0.0001588377,0.001054931,0.00004662787,0.0001936352,0.0004920815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1542998,"threshold_uncertainty_score":0.9996634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01897090738087662,"score_gpt":0.2835828388358142,"score_spread":0.2646119314549376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}