{"id":"W4206174687","doi":"10.1182/blood.v124.21.lba-5.lba-5","title":"A Randomized Phase II Study of Azacitidine Combined with Lenalidomide or with Vorinostat Vs. Azacitidine Monotherapy in Higher-Risk Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML): North American Intergroup Study SWOG S1117","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Lenalidomide; Azacitidine; Internal medicine; Chronic myelomonocytic leukemia; International Prognostic Scoring System; Decitabine; Oncology; Myelodysplastic syndromes; Hypomethylating agent; Phases of clinical research; Clinical endpoint; Adverse effect; Gastroenterology; Randomized controlled trial; Clinical trial; Bone marrow; Multiple myeloma; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00228351,0.002237218,0.003496643,0.0006064695,0.0005733417,0.00139377,0.001389683,0.002125012,0.00982941],"category_scores_gemma":[0.001695415,0.001151044,0.001887373,0.0005458445,0.001721923,0.001506309,0.000621339,0.004107169,0.001720374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001270624,"about_ca_system_score_gemma":0.002253542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00140884,"about_ca_topic_score_gemma":0.003644741,"domain_scores_codex":[0.9992583,0.0004366079,0.00003412232,0.000121909,0.00004916108,0.00009986045],"domain_scores_gemma":[0.9986423,0.0002827297,0.0002599159,0.0001206782,0.00008206744,0.0006123856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9657003,0.01861085,0.0006503139,0.0003245417,0.0007428362,0.00003942199,0.00005923537,0.0004017231,0.003241362,0.0001362359,0.001201902,0.008891273],"study_design_scores_gemma":[0.9234952,0.0740904,0.0009193724,0.00001697362,0.0002560945,0.00002136682,0.00002263355,0.0002789943,0.0002258802,0.0001327301,0.0005285925,0.00001174991],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774371,0.002756274,0.0008224508,0.001227882,0.0009700197,0.01157018,0.002051095,0.0001635548,0.003001425],"genre_scores_gemma":[0.9648616,0.002726897,0.002709504,0.002511762,0.000798749,0.01656069,0.002811463,0.0000608549,0.006958483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00982941,"threshold_uncertainty_score":0.03288263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01897090738087662,"score_gpt":0.2835828388358142,"score_spread":0.2646119314549376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}