{"id":"W4206209764","doi":"10.1007/s11306-021-01864-6","title":"Metabolite profiling reveals a connection between aldehyde dehydrogenase 1A3 and GABA metabolism in breast cancer metastasis","year":2022,"lang":"en","type":"article","venue":"Metabolomics","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; University of Prince Edward Island; Dalhousie University","funders":"Canadian Institutes of Health Research; Killam Trusts; Dalhousie University; Nova Scotia Health Research Foundation; Dalhousie Medical Research Foundation; QEII Foundation; Cancer Research Institute; Health Sciences Centre Foundation; Beatrice Hunter Cancer Research Institute","keywords":"Breast cancer; Metastasis; Cancer research; Biology; Metabolomics; Metabolite; Transcriptome; Cancer; Aldehyde dehydrogenase; Pathology; Medicine; Bioinformatics; Gene expression; Endocrinology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00163823,0.0004411819,0.001443554,0.000590142,0.0003014216,0.00005244838,0.0001853036,0.0001025393,0.0005497791],"category_scores_gemma":[0.00007277131,0.0004244873,0.0003036068,0.001122184,0.00009100157,0.0002337873,0.0003029178,0.0007187107,0.00000820667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002544053,"about_ca_system_score_gemma":0.0002861472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00124825,"about_ca_topic_score_gemma":0.00008199596,"domain_scores_codex":[0.996594,0.0004101566,0.0008294694,0.000852343,0.0005915028,0.0007225948],"domain_scores_gemma":[0.9985532,0.0001138537,0.0003160172,0.0005224537,0.0001298858,0.0003645434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003233872,0.001238962,0.3928665,0.0008673506,0.004187176,0.0003492242,0.002262513,0.001111904,0.406218,0.01199445,0.001751679,0.1739184],"study_design_scores_gemma":[0.01869844,0.0002693877,0.3083722,0.000125219,0.01235662,0.001537175,0.002901246,0.001263202,0.2076946,0.002301597,0.4422249,0.002255409],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9573795,0.03493537,0.0001555884,0.00265678,0.0005638174,0.001066247,0.002972853,0.00009452394,0.0001753051],"genre_scores_gemma":[0.9869511,0.005246064,0.004626514,0.001354275,0.0005128601,0.0006507639,0.000225874,0.0001032134,0.0003293623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4404732,"threshold_uncertainty_score":0.9998207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02310657470690592,"score_gpt":0.2847857474957908,"score_spread":0.2616791727888849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}