{"id":"W4206238555","doi":"10.1016/j.molcel.2021.12.026","title":"CRISPR-based genome editing through the lens of DNA repair","year":2022,"lang":"en","type":"article","venue":"Molecular Cell","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":210,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Cancer Institute","keywords":"Genome editing; DNA repair; CRISPR; Recombinase; Transposase; DNA; Genome; Nucleotide excision repair; DNA damage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009038171,0.0007189891,0.0007402016,0.0008997854,0.0006157705,0.002600305,0.001325876,0.001529372,0.003804258],"category_scores_gemma":[0.00123745,0.0005239964,0.0004315844,0.0004749426,0.00204981,0.002250198,0.001868157,0.003280144,0.001385276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001426776,"about_ca_system_score_gemma":0.001122911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001397684,"about_ca_topic_score_gemma":0.001586173,"domain_scores_codex":[0.9990828,0.0001056043,0.00003505565,0.0002062602,0.0004826364,0.00008769075],"domain_scores_gemma":[0.9992367,0.0002464846,0.0001679009,0.0001379732,0.00009093137,0.0001199521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001998504,0.00004108396,0.0003001008,0.0003846481,0.00004313869,0.0003571429,0.0001744348,0.00243044,0.7197978,0.2348228,0.002944638,0.03850385],"study_design_scores_gemma":[0.00006886871,0.0001859636,0.0006599317,0.00008334935,0.00003822892,0.001205123,0.0001550516,0.01099594,0.841462,0.03762421,0.1074248,0.0000964222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.1268368,0.02081874,0.7343521,0.0106191,0.002514775,0.0002099253,0.0008673075,0.005464229,0.09831707],"genre_scores_gemma":[0.7843699,0.01412991,0.1526395,0.001352179,0.0003609966,0.0001372104,0.0003218223,0.0005777546,0.04611077],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003804258,"threshold_uncertainty_score":0.01272655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007107046487407899,"score_gpt":0.2472092822371666,"score_spread":0.2401022357497588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}