{"id":"W4206238555","doi":"10.1016/j.molcel.2021.12.026","title":"CRISPR-based genome editing through the lens of DNA repair","year":2022,"lang":"en","type":"article","venue":"Molecular Cell","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":210,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Cancer Institute","keywords":"Genome editing; DNA repair; CRISPR; Recombinase; Transposase; DNA; Genome; Nucleotide excision repair; DNA damage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001675489,0.0001240748,0.0001068831,0.00002198893,0.0001095896,0.000006651567,0.0002488502,0.00004332503,0.00007074536],"category_scores_gemma":[0.0000222717,0.0001145091,0.0001923533,0.0001126219,0.00004412278,0.000001266419,0.0002005116,0.0001244011,0.000002599506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001232326,"about_ca_system_score_gemma":0.00005624278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000195111,"about_ca_topic_score_gemma":0.000002812415,"domain_scores_codex":[0.9990777,0.00007256479,0.0001855281,0.0002539881,0.0001930617,0.0002171492],"domain_scores_gemma":[0.9993706,0.000009486576,0.00006658924,0.0004922181,0.00003571867,0.00002537767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000012059,0.00004374439,0.00005563314,0.00002898941,0.00002377943,0.000009958613,0.000110893,0.04560531,0.9532213,0.00007411683,0.0007621936,0.0000520499],"study_design_scores_gemma":[0.0002690738,0.0001826969,0.0001032202,0.000002033694,0.00002569669,0.000004453653,0.0002216876,0.0005161653,0.7958887,0.000029932,0.2026274,0.0001289492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.876999,0.00557945,0.1055848,0.0005821785,0.0003983436,0.0003771704,0.00006351905,0.00005281971,0.01036277],"genre_scores_gemma":[0.9969482,0.00001691937,0.001907913,0.0006536232,0.000104114,0.00003853996,0.00008037188,0.00003184077,0.0002184116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2018652,"threshold_uncertainty_score":0.4669544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007107046487407899,"score_gpt":0.2472092822371666,"score_spread":0.2401022357497588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}