{"id":"W4206239958","doi":"10.1021/acs.bioconjchem.1c00510","title":"Targeted Anti-Cancer Provascular Therapy Using Ultrasound, Microbubbles, and Nitrite to Increase Radiotherapy Efficacy","year":2022,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canada First Research Excellence Fund; Cancer Research Society","keywords":"Perfusion; Sodium nitrite; Prostate cancer; Chemistry; Nitrite; Nitric oxide; Microbubbles; Cancer research; Hypoxia (environmental); Radiation therapy; Cancer; Medicine; Internal medicine; Ultrasound; Radiology; Oxygen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002470531,0.0003402905,0.0003492008,0.0001794756,0.00009442055,0.0001938032,0.0002091864,0.0003367088,0.0007605148],"category_scores_gemma":[0.0001223767,0.0001230766,0.0002932188,0.0001073506,0.00021899,0.0002387431,0.0001966799,0.00051884,0.0001026828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000179323,"about_ca_system_score_gemma":0.000203908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004212692,"about_ca_topic_score_gemma":0.0007985008,"domain_scores_codex":[0.9998794,0.00002327751,0.000006206493,0.00002852064,0.00003748674,0.00002516921],"domain_scores_gemma":[0.9999362,0.00001525573,0.00001867534,0.000004077628,0.000009522852,0.00001614753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001074723,0.00004400977,0.00004389462,0.00006060902,0.000004264167,0.00001583172,0.00001534858,0.0001103468,0.997797,0.00006156424,0.00003199721,0.001707587],"study_design_scores_gemma":[0.00002707085,0.001588473,0.0009505313,0.000009152271,0.0000248683,0.00007785115,0.00001405186,0.001275151,0.9942076,0.00003204394,0.001787562,0.00000571181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836669,0.004651476,0.00980301,0.0001739932,0.0000834009,0.00009334028,0.0001127457,0.000162942,0.001252069],"genre_scores_gemma":[0.9865745,0.002253819,0.008102638,0.0001389764,0.00004061105,0.0001374651,0.0001309667,0.00003257232,0.002588548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007605148,"threshold_uncertainty_score":0.002544224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01172438720628498,"score_gpt":0.2251668276550536,"score_spread":0.2134424404487686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}