{"id":"W4206239958","doi":"10.1021/acs.bioconjchem.1c00510","title":"Targeted Anti-Cancer Provascular Therapy Using Ultrasound, Microbubbles, and Nitrite to Increase Radiotherapy Efficacy","year":2022,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canada First Research Excellence Fund; Cancer Research Society","keywords":"Perfusion; Sodium nitrite; Prostate cancer; Chemistry; Nitrite; Nitric oxide; Microbubbles; Cancer research; Hypoxia (environmental); Radiation therapy; Cancer; Medicine; Internal medicine; Ultrasound; Radiology; Oxygen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001063344,0.0002351255,0.0002303968,0.00004198792,0.0002755893,0.00006919805,0.0002167873,0.00006732239,0.0005699298],"category_scores_gemma":[0.000008240661,0.0002525364,0.00007991223,0.0002877604,0.00005017965,0.00005167368,0.00003549435,0.0002059843,0.000004012983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001384112,"about_ca_system_score_gemma":0.00004336402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001040775,"about_ca_topic_score_gemma":9.016914e-7,"domain_scores_codex":[0.9990124,0.00002043104,0.0001978205,0.0003274847,0.0001435058,0.0002983899],"domain_scores_gemma":[0.9994081,0.00004134244,0.00003315471,0.0003296035,0.0000278925,0.0001599692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002015595,0.00007040824,0.0008404993,0.00004915993,0.0001329379,0.000002285101,0.0001858828,0.004816922,0.9922158,0.000003392105,0.0004302413,0.001232296],"study_design_scores_gemma":[0.001318027,0.00001510804,0.0005424032,0.00001424837,0.00002540354,0.00006971967,0.0001146727,0.0008924527,0.8096098,0.00001125032,0.1869176,0.0004692512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884592,0.0101657,0.0002438917,0.00005674404,0.00005190402,0.0004559055,0.0001868916,0.0002473792,0.0001324163],"genre_scores_gemma":[0.9955844,0.001717043,0.001521576,0.0003018352,0.000200241,0.0002859413,0.0001042272,0.00009085872,0.0001938847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1864874,"threshold_uncertainty_score":0.9999927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01172438720628498,"score_gpt":0.2251668276550536,"score_spread":0.2134424404487686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}