{"id":"W4206255712","doi":"10.3390/cells11010136","title":"Rescue of Mutant CFTR Trafficking Defect by the Investigational Compound MCG1516A","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fundação para a Ciência e a Tecnologia; Gilead Sciences; Cystic Fibrosis Foundation","keywords":"Mutant; Chemistry; Mutation; Wild type; Molecular biology; Cell biology; Pharmacology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001374709,0.0003296602,0.0003580598,0.0001641473,0.0001002947,0.0001818291,0.0002832351,0.0002896926,0.001331511],"category_scores_gemma":[0.00008900883,0.00009924714,0.0003239055,0.0001099256,0.0001625092,0.0001840003,0.0001977791,0.0004895684,0.0003484051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002552964,"about_ca_system_score_gemma":0.0003347681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008699578,"about_ca_topic_score_gemma":0.001339534,"domain_scores_codex":[0.9999112,0.00001100278,0.00001188828,0.00001940271,0.0000260819,0.00002040362],"domain_scores_gemma":[0.999923,0.000008730281,0.00002548739,0.00001086031,0.00001052762,0.00002139312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001088496,0.00002103828,0.0001456568,0.00004712282,0.000006118624,0.00007928013,0.00001004906,0.00007543264,0.9976549,0.00005583834,0.00004103393,0.001754769],"study_design_scores_gemma":[0.00003633183,0.0009591023,0.002515798,0.00001278993,0.00001877766,0.0005559652,0.00001753197,0.0003768555,0.9916751,0.00002518567,0.003800902,0.000005678308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934977,0.003089636,0.0009315061,0.000118604,0.00003457811,0.00004607112,0.0007166641,0.00008568748,0.001479642],"genre_scores_gemma":[0.9919999,0.002274,0.002103211,0.0000617046,0.000007625967,0.00004184478,0.0008281313,0.0000231762,0.002660527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001331511,"threshold_uncertainty_score":0.004454315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02121789825001593,"score_gpt":0.2833538597613994,"score_spread":0.2621359615113835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}