{"id":"W4206264159","doi":"10.1038/s41423-021-00809-2","title":"Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates","year":2022,"lang":"en","type":"article","venue":"Cellular and Molecular Immunology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Medicago (Canada)","funders":"National Institutes of Health; Australian Government; Battelle","keywords":"Immunogenicity; Adjuvant; Medicine; Immunology; Immune system; Virology; Nasal administration","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004330642,0.0001892193,0.0004508012,0.0002340832,0.0003046104,0.00001766754,0.00009545759,0.0001072414,0.00001062918],"category_scores_gemma":[0.0001732336,0.0001857195,0.00005796284,0.0002535134,0.0001274814,0.00006484635,0.0002742676,0.0002224334,3.675715e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001435012,"about_ca_system_score_gemma":0.0002374551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001949832,"about_ca_topic_score_gemma":0.000277567,"domain_scores_codex":[0.9984374,0.0001881858,0.0004497184,0.0004056045,0.000146736,0.0003723555],"domain_scores_gemma":[0.9993847,0.00009431543,0.0001362367,0.0002584217,0.00006825376,0.00005806346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004167451,0.0002358502,0.00317569,0.000251175,0.0001664835,0.00005557841,0.0006459284,0.000001389361,0.989517,0.0004090036,0.00002920938,0.001345276],"study_design_scores_gemma":[0.01476379,0.002385381,0.003191976,0.00004329606,0.0001407827,0.0003126289,0.000525978,0.005135356,0.9555509,0.001005681,0.01667876,0.0002654547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854168,0.007740027,0.003805328,0.0007428044,0.00006281192,0.002091323,0.00009078321,0.0000374394,0.00001263802],"genre_scores_gemma":[0.9971164,0.000169497,0.00009825829,0.001987628,0.00000417855,0.0004250275,0.0001513319,0.00003026964,0.00001744361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03396605,"threshold_uncertainty_score":0.7573423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01749187303590394,"score_gpt":0.2862473600213467,"score_spread":0.2687554869854427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}