{"id":"W4206264159","doi":"10.1038/s41423-021-00809-2","title":"Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates","year":2022,"lang":"en","type":"article","venue":"Cellular and Molecular Immunology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Medicago (Canada)","funders":"National Institutes of Health; Australian Government; Battelle","keywords":"Immunogenicity; Adjuvant; Medicine; Immunology; Immune system; Virology; Nasal administration","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000296613,0.0004820863,0.0002543496,0.0002033122,0.000154988,0.00025878,0.0002468602,0.0005079001,0.0008385381],"category_scores_gemma":[0.0002355983,0.0001746382,0.0002321862,0.0001007506,0.0003674284,0.0002399587,0.00009943858,0.0007615667,0.0002442705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000266887,"about_ca_system_score_gemma":0.0002983169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006198345,"about_ca_topic_score_gemma":0.0005976924,"domain_scores_codex":[0.9998208,0.00004897876,0.0000106651,0.00002823778,0.00004769657,0.00004376073],"domain_scores_gemma":[0.9998832,0.00002036277,0.00003439275,0.00001380193,0.00001793663,0.00003033668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002242119,0.0006929936,0.0002954757,0.00008198203,0.00001872529,0.00006167348,0.00006969613,0.0002265968,0.9934807,0.00009329033,0.00008219262,0.002654595],"study_design_scores_gemma":[0.0007131186,0.05374455,0.007906007,0.00003644007,0.0001081925,0.000507339,0.0001074608,0.001798053,0.9304518,0.0001940667,0.004414552,0.000018602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983963,0.0005620225,0.0004627318,0.00004602389,0.00002887835,0.00004119578,0.0001102974,0.00001924528,0.0003331591],"genre_scores_gemma":[0.9975867,0.0003939339,0.0005986558,0.00005087201,0.00001727749,0.00006189508,0.000302252,0.000007565214,0.0009808142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008385381,"threshold_uncertainty_score":0.002805233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01749187303590394,"score_gpt":0.2862473600213467,"score_spread":0.2687554869854427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}