{"id":"W4206273143","doi":"10.1021/acsmedchemlett.1c00648","title":"Antibacterial Activity of Metergoline Analogues: Revisiting the Ergot Alkaloid Scaffold for Antibiotic Discovery","year":2022,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Plant and fungal interactions","field":"Agricultural and Biological Sciences","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; McMaster University","keywords":"Microbiology; Norfloxacin; Chemistry; Antibacterial activity; Escherichia coli; Antibiotics; Bacteria; Biology; Biochemistry; Pharmacology; Ciprofloxacin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003821354,0.0005222241,0.0004974796,0.0004409575,0.0001473687,0.0005525906,0.0004946195,0.0003835827,0.0008944371],"category_scores_gemma":[0.0002490033,0.0001944782,0.0002898871,0.0002852652,0.0004148085,0.0007867917,0.0004061933,0.0006606625,0.0004743869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006150919,"about_ca_system_score_gemma":0.0004685486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005206778,"about_ca_topic_score_gemma":0.001596315,"domain_scores_codex":[0.9998869,0.00002257697,0.00001087739,0.00001591662,0.0000335137,0.0000303103],"domain_scores_gemma":[0.9998945,0.00002022181,0.00002605109,0.00001019547,0.00002562016,0.00002331364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002994835,0.0001743177,0.000564412,0.0007508099,0.00001706319,0.0007130596,0.0001449031,0.002098067,0.9509254,0.002479672,0.0003882928,0.04144448],"study_design_scores_gemma":[0.0004774859,0.008684903,0.006386864,0.0004114991,0.0001317112,0.003259643,0.000308964,0.006749782,0.8576682,0.002498335,0.1133259,0.00009679331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8988339,0.0668022,0.0192667,0.002267862,0.0001681739,0.0004911968,0.0006527211,0.0003601416,0.01115718],"genre_scores_gemma":[0.9229718,0.05600096,0.01606877,0.0005974377,0.00008891398,0.0001136353,0.0006590318,0.0000395364,0.003459824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008944371,"threshold_uncertainty_score":0.004462838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01946489122623111,"score_gpt":0.2302953979305311,"score_spread":0.2108305067043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}