{"id":"W4206273143","doi":"10.1021/acsmedchemlett.1c00648","title":"Antibacterial Activity of Metergoline Analogues: Revisiting the Ergot Alkaloid Scaffold for Antibiotic Discovery","year":2022,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Plant and fungal interactions","field":"Agricultural and Biological Sciences","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; McMaster University","keywords":"Microbiology; Norfloxacin; Chemistry; Antibacterial activity; Escherichia coli; Antibiotics; Bacteria; Biology; Biochemistry; Pharmacology; Ciprofloxacin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003150373,0.0001217129,0.0002019098,0.00000659389,0.0003456815,0.00003066556,0.0003177522,0.00002956847,0.000113017],"category_scores_gemma":[0.00007808203,0.00004772692,0.0001285759,0.0001995377,0.00008527829,0.000122939,0.0001040129,0.0001881041,7.627571e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003490821,"about_ca_system_score_gemma":0.000009063443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000146072,"about_ca_topic_score_gemma":0.00001156001,"domain_scores_codex":[0.9990723,0.0000528926,0.0002020075,0.0002168894,0.000235555,0.0002203917],"domain_scores_gemma":[0.9991465,0.000517863,0.00019479,0.00007308617,0.00002616453,0.00004156999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001539398,0.00004269233,0.0004448373,0.00003666904,0.00003373911,0.000004428223,0.00003413257,0.000006561729,0.9941792,0.000004440932,0.002443017,0.002616358],"study_design_scores_gemma":[0.0004866858,0.0001657437,0.01032001,0.00009854632,0.0001322166,0.00009351154,0.0008768599,0.0001201655,0.9673461,0.0000173465,0.02006631,0.0002765277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912697,0.00006153826,0.00001574221,0.00753429,0.0004218473,0.0001274766,0.0004235639,0.00001917293,0.0001266545],"genre_scores_gemma":[0.9965954,0.00001524947,0.00001571592,0.0006194076,0.002306959,0.00001130091,0.000343081,0.000001330404,0.0000914943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02683311,"threshold_uncertainty_score":0.2658737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01946489122623111,"score_gpt":0.2302953979305311,"score_spread":0.2108305067043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}