{"id":"W4206274130","doi":"10.1371/journal.ppat.1010245","title":"The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription","year":2022,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; NIH Office of the Director; Oregon National Primate Research Center; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Fonds de Recherche du Québec - Santé; Frederick National Laboratory for Cancer Research; GlaxoSmithKline","keywords":"Simian immunodeficiency virus; In vivo; Biology; Virology; Viremia; In vitro; CD8; Cytotoxic T cell; Virus; Pharmacology; Immunology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002027448,0.0001200856,0.0001530007,0.00006586083,0.0006908368,0.00001334731,0.0001377562,0.00006057554,0.0003421596],"category_scores_gemma":[0.00003077691,0.00008650492,0.00007988177,0.0001139113,0.0001838918,0.00002103651,0.00006373049,0.0002599131,0.0001064564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006441065,"about_ca_system_score_gemma":0.0001173839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004673349,"about_ca_topic_score_gemma":0.00001944274,"domain_scores_codex":[0.9988808,0.000317658,0.0001827495,0.0002233285,0.00008810321,0.000307377],"domain_scores_gemma":[0.9995468,0.00005329851,0.00006794273,0.0002503252,0.00004895956,0.00003266131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002974622,0.0004468377,0.0006918337,0.00002302275,0.0001809176,0.00003176695,0.000830138,0.00000301793,0.9897216,0.0001157263,0.0003604286,0.007297266],"study_design_scores_gemma":[0.002180206,0.0009429365,0.003153308,0.00002088224,0.00009252839,0.00001685262,0.0007651914,0.00002611524,0.9654101,0.00009812135,0.02714311,0.0001506179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927856,0.002800421,0.0000251376,0.001995452,0.00005471562,0.0006902664,0.001293684,0.00002389079,0.0003308377],"genre_scores_gemma":[0.998124,0.00004613714,0.00004570405,0.0000913812,0.000008395582,0.000403792,0.0002238387,0.00001379417,0.001042951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02678268,"threshold_uncertainty_score":0.5313428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02167835049334476,"score_gpt":0.2292576146198276,"score_spread":0.2075792641264828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}