{"id":"W4206274130","doi":"10.1371/journal.ppat.1010245","title":"The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription","year":2022,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; NIH Office of the Director; Oregon National Primate Research Center; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Fonds de Recherche du Québec - Santé; Frederick National Laboratory for Cancer Research; GlaxoSmithKline","keywords":"Simian immunodeficiency virus; In vivo; Biology; Virology; Viremia; In vitro; CD8; Cytotoxic T cell; Virus; Pharmacology; Immunology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008408997,0.0003691113,0.0001890607,0.0002309987,0.000147831,0.0002485263,0.000107801,0.0001947765,0.003416453],"category_scores_gemma":[0.00007516029,0.00009832455,0.0002650243,0.0001691593,0.0001365026,0.0001778735,0.0001646015,0.0004864126,0.0005108421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001518603,"about_ca_system_score_gemma":0.0002147409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003155359,"about_ca_topic_score_gemma":0.000856229,"domain_scores_codex":[0.9999404,0.00001058573,0.000009406634,0.00001172813,0.00001348289,0.00001442677],"domain_scores_gemma":[0.9999624,0.000005460444,0.00001342967,0.000005611407,0.000003491516,0.000009518326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003047694,0.00009782254,0.0003170651,0.0001806222,0.00001234543,0.00005878633,0.00001322238,0.0001559164,0.9922149,0.00009030083,0.0001025921,0.006451728],"study_design_scores_gemma":[0.00009292889,0.002643773,0.005308994,0.00002789646,0.00004551009,0.0004165356,0.00004153402,0.0003912908,0.984293,0.00008760161,0.006640633,0.00001023561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862267,0.006542142,0.001352098,0.0001742595,0.00007124806,0.00007810426,0.0007986432,0.00008396699,0.004672723],"genre_scores_gemma":[0.9897816,0.003763984,0.001854889,0.00007148586,0.00001627443,0.00005566655,0.0009303112,0.00000971839,0.003516051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003416453,"threshold_uncertainty_score":0.01142913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02167835049334476,"score_gpt":0.2292576146198276,"score_spread":0.2075792641264828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}