{"id":"W4206280902","doi":"10.1002/alz.054702","title":"A machine learning enrichment strategy for presymptomatic cohorts in Alzheimer’s disease clinical trials","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"","keywords":"Disease; Cognitive impairment; Dementia; Medicine; Cognitive decline; Gerontology; Gray (unit); Internal medicine; Psychology; Nuclear medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04827373,0.001163585,0.002215763,0.002579221,0.0008455354,0.001548063,0.002199421,0.001734923,0.004926001],"category_scores_gemma":[0.09092291,0.0005928105,0.001756107,0.001088973,0.0007178443,0.001475125,0.001871698,0.002022854,0.001119316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009045398,"about_ca_system_score_gemma":0.003213318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001362315,"about_ca_topic_score_gemma":0.002472191,"domain_scores_codex":[0.981951,0.01503549,0.0008861982,0.001124469,0.0006861155,0.0003167313],"domain_scores_gemma":[0.9426296,0.04692879,0.002782356,0.002592038,0.003681339,0.001385754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.01632124,0.002308975,0.2004609,0.001427736,0.004781959,0.00140469,0.0005290049,0.1421797,0.0055288,0.006802288,0.01762524,0.6006294],"study_design_scores_gemma":[0.001338104,0.001325504,0.01151014,0.0002124695,0.001122675,0.0002669245,0.00007211737,0.9642424,0.002802643,0.0135493,0.003507492,0.00005029469],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2723796,0.003398132,0.7005662,0.006038773,0.0004775505,0.006077638,0.001850191,0.004503067,0.004708849],"genre_scores_gemma":[0.8136411,0.0002399339,0.1779112,0.001432069,0.0002079866,0.003646112,0.001289933,0.0001105817,0.001521036],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.04827373,"threshold_uncertainty_score":0.2552989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.143655745609987,"score_gpt":0.44303293813051,"score_spread":0.299377192520523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}