{"id":"W4206319885","doi":"10.1002/jha2.375","title":"Phase Ib study of combinations of avadomide (CC‐122), CC‐223, CC‐292, and rituximab in patients with relapsed/refractory diffuse large B‐cell lymphoma","year":2022,"lang":"en","type":"article","venue":"eJHaem","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Celgene; Bristol-Myers Squibb","keywords":"Medicine; Rituximab; Internal medicine; Tolerability; Refractory (planetary science); Adverse effect; Diffuse large B-cell lymphoma; Gastroenterology; Clinical endpoint; Neutropenia; Phases of clinical research; Lymphoma; Pharmacodynamics; Oncology; Toxicity; Pharmacology; Clinical trial; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005386309,0.0001993902,0.0005839348,0.0004455869,0.0001346085,0.000009720708,0.0001948727,0.00005768029,0.0001487711],"category_scores_gemma":[0.00008446584,0.0001824773,0.00006526225,0.0005781693,0.0001335597,0.00009898718,0.0002446169,0.0003644185,0.000006006182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002340952,"about_ca_system_score_gemma":0.0001610457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003038869,"about_ca_topic_score_gemma":0.0001616116,"domain_scores_codex":[0.9974994,0.0003029064,0.0004907367,0.0003739321,0.0009849813,0.00034806],"domain_scores_gemma":[0.9986547,0.0002076209,0.0002110519,0.0005895407,0.000191414,0.0001457168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"nonrandomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.00328588,0.95826,0.02801596,0.00008660316,0.0001225149,0.0000799936,0.005805792,1.357591e-7,0.000346788,0.00003640887,0.0004111667,0.00354878],"study_design_scores_gemma":[0.9635131,0.01114315,0.01733102,0.00004063726,0.000093035,0.000005184691,0.004149366,0.0001209807,0.000814729,0.00002723474,0.00259765,0.000163861],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968036,0.0003242002,0.000004807275,0.00006194694,0.00009093159,0.001502239,0.0001165514,0.00002600972,0.001069684],"genre_scores_gemma":[0.9973129,0.00003507405,0.00003841298,0.00005887646,0.00001743349,0.00009617044,0.00009447912,0.00005316554,0.002293511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9602273,"threshold_uncertainty_score":0.7441208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01467472234611209,"score_gpt":0.2874215979630838,"score_spread":0.2727468756169717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}