{"id":"W4206319885","doi":"10.1002/jha2.375","title":"Phase Ib study of combinations of avadomide (CC‐122), CC‐223, CC‐292, and rituximab in patients with relapsed/refractory diffuse large B‐cell lymphoma","year":2022,"lang":"en","type":"article","venue":"eJHaem","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Celgene; Bristol-Myers Squibb","keywords":"Medicine; Rituximab; Internal medicine; Tolerability; Refractory (planetary science); Adverse effect; Diffuse large B-cell lymphoma; Gastroenterology; Clinical endpoint; Neutropenia; Phases of clinical research; Lymphoma; Pharmacodynamics; Oncology; Toxicity; Pharmacology; Clinical trial; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001207425,0.0009694688,0.001337216,0.0003620934,0.0003089528,0.000808079,0.000734826,0.0006509366,0.001864745],"category_scores_gemma":[0.0006115373,0.0005332197,0.0008252925,0.0003743728,0.0006188278,0.0006238385,0.0002828079,0.002055695,0.0004805102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009037895,"about_ca_system_score_gemma":0.001220484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001250812,"about_ca_topic_score_gemma":0.003607615,"domain_scores_codex":[0.999655,0.0001714778,0.00002245677,0.00005186615,0.00003616983,0.00006306331],"domain_scores_gemma":[0.999567,0.00005289072,0.00007812136,0.00003596382,0.00002854057,0.0002373764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4972695,0.1402117,0.01932095,0.0009026931,0.002362083,0.0006381392,0.0006311506,0.006636684,0.1421981,0.0006036517,0.004806651,0.1844187],"study_design_scores_gemma":[0.2696327,0.698819,0.01528985,0.00003772265,0.0005967282,0.0004848461,0.0001366498,0.002187366,0.009267236,0.0001921874,0.003317749,0.00003787163],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954109,0.001434933,0.000302754,0.0001848049,0.00005242255,0.00106508,0.0003638132,0.00004665876,0.001138653],"genre_scores_gemma":[0.9954134,0.001176787,0.0009271093,0.0002739777,0.00006593727,0.0005930662,0.0007843439,0.00001346811,0.0007519411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001864745,"threshold_uncertainty_score":0.006557465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01467472234611209,"score_gpt":0.2874215979630838,"score_spread":0.2727468756169717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}