{"id":"W4206329752","doi":"10.21203/rs.3.rs-1273263/v1","title":"Inhibition of TGFb-induced Fibroblast to Myofibroblast Transition by Conditioned Medium from Human Rhinovirus-infected Airway Epithelial Cells is Mediated by Prostaglandin E2","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; GlaxoSmithKline","keywords":"Myofibroblast; Fibroblast; Respiratory epithelium; Epithelium; Transforming growth factor; Rhinovirus; Extracellular matrix; Cell biology; Blot; Downregulation and upregulation; Prostaglandin E2; Immunology; Biology; Chemistry; Medicine; Cell culture; Respiratory system; Pathology; Internal medicine; Endocrinology; Fibrosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003736339,0.00067634,0.0005573707,0.0002821201,0.0002066052,0.0003021957,0.0002412535,0.000252617,0.001990051],"category_scores_gemma":[0.000220268,0.0001539844,0.0005213057,0.0001574346,0.000330839,0.0001469645,0.0003077756,0.000681894,0.0004980151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001948334,"about_ca_system_score_gemma":0.0003462924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000594391,"about_ca_topic_score_gemma":0.0007495911,"domain_scores_codex":[0.9996985,0.00007939064,0.00003736483,0.0000351695,0.00007577112,0.00007375061],"domain_scores_gemma":[0.9997792,0.00009106338,0.00003023729,0.00002479398,0.00002207158,0.00005263141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009177357,0.0001425909,0.0002486918,0.000106574,0.00001205504,0.00009239629,0.00002697495,0.00004467839,0.9967089,0.00004012507,0.00006714265,0.001592184],"study_design_scores_gemma":[0.0001494983,0.001814406,0.008156177,0.00002718159,0.00004014555,0.0002331796,0.00003684195,0.0007397768,0.9870434,0.00003224721,0.001719663,0.000007366583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889241,0.005745922,0.002282747,0.0001775426,0.0001770675,0.0001106537,0.0007472343,0.00006328557,0.001771356],"genre_scores_gemma":[0.9899225,0.00254032,0.003475176,0.0001118531,0.00008486809,0.0001507656,0.001855959,0.00001809024,0.001840523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001990051,"threshold_uncertainty_score":0.006657362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02665067954993716,"score_gpt":0.3353611884008195,"score_spread":0.3087105088508823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}