{"id":"W4206331271","doi":"10.1093/cei/uxab011","title":"Evaluation of a gene expression biomarker to identify operationally tolerant liver transplant recipients: the LITMUS trial","year":2021,"lang":"en","type":"article","venue":"Clinical & Experimental Immunology","topic":"Organ Transplantation Techniques and Outcomes","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Heart and Stroke Foundation of Canada","keywords":"Litmus; Biomarker; Immunology; Liver transplantation; Gene expression; Biology; Medicine; Transplantation; Gene; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001373358,0.0001441173,0.0003983167,0.00006072235,0.00008902988,0.00001759664,0.0001511435,0.0001920349,0.001519157],"category_scores_gemma":[0.0002589575,0.00009984904,0.0002495096,0.0001524862,0.000158386,0.00007286583,0.00004545801,0.000191867,0.00005030927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007745036,"about_ca_system_score_gemma":0.0002524132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001980684,"about_ca_topic_score_gemma":0.000004586403,"domain_scores_codex":[0.9973101,0.0007119728,0.0009072241,0.0003578382,0.0005408072,0.0001720816],"domain_scores_gemma":[0.9987167,0.0002597868,0.0001256719,0.0004066806,0.0004143349,0.0000768768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01284685,0.001401704,0.002074147,0.00001146797,0.0002367837,0.00004963067,0.001154503,0.00000215824,0.9777992,0.0001076113,0.0004123753,0.003903504],"study_design_scores_gemma":[0.02250888,0.001113965,0.09466359,0.0001262739,0.0003044728,0.00009248644,0.0002862918,0.000096271,0.8801833,0.00002757144,0.0004852487,0.0001116967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992189,0.003150384,0.0009338883,0.001253914,0.001105406,0.001044899,0.00002844436,0.00003649791,0.0002575735],"genre_scores_gemma":[0.9945801,0.0005863414,0.003114494,0.001098952,0.0001319415,0.0001486552,0.0001515188,0.00001761363,0.0001703806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09761601,"threshold_uncertainty_score":0.9993936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1512986297874296,"score_gpt":0.4770536121979876,"score_spread":0.325754982410558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}