{"id":"W4206331271","doi":"10.1093/cei/uxab011","title":"Evaluation of a gene expression biomarker to identify operationally tolerant liver transplant recipients: the LITMUS trial","year":2021,"lang":"en","type":"article","venue":"Clinical & Experimental Immunology","topic":"Organ Transplantation Techniques and Outcomes","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Heart and Stroke Foundation of Canada","keywords":"Litmus; Biomarker; Immunology; Liver transplantation; Gene expression; Biology; Medicine; Transplantation; Gene; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001125279,0.0004784568,0.0008853513,0.000235434,0.0001498201,0.0006416206,0.000247198,0.0005463575,0.0007822019],"category_scores_gemma":[0.0004700271,0.0001317198,0.0004507884,0.0001723197,0.0003662977,0.000382519,0.0002501162,0.0009205157,0.000135113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003312262,"about_ca_system_score_gemma":0.0002880089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008001579,"about_ca_topic_score_gemma":0.0002001596,"domain_scores_codex":[0.9997435,0.0001447281,0.00001520323,0.00003381325,0.0000258108,0.00003681468],"domain_scores_gemma":[0.9996552,0.00006137927,0.0001052748,0.00002324457,0.00002276057,0.0001321769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5885624,0.007859731,0.09603295,0.0007835113,0.001045159,0.0003528332,0.0002249199,0.002362543,0.1372359,0.0005224111,0.001393114,0.1636246],"study_design_scores_gemma":[0.1733241,0.6087654,0.1639587,0.0001676835,0.00134288,0.001238605,0.0001840613,0.006420569,0.03826151,0.0005952729,0.005646914,0.00009424371],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983459,0.0008873718,0.0001735074,0.0001090335,0.00001630488,0.0001151828,0.00009189204,0.00001365748,0.0002472136],"genre_scores_gemma":[0.9976251,0.0003001883,0.0005776205,0.0004566066,0.00003448005,0.000293954,0.0003513534,0.00000400365,0.0003568122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001125279,"threshold_uncertainty_score":0.005951107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1512986297874296,"score_gpt":0.4770536121979876,"score_spread":0.325754982410558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}