{"id":"W4206347499","doi":"10.3389/fmed.2021.802063","title":"Targeting Pyroptotic Cell Death Pathways in Retinal Disease","year":2022,"lang":"en","type":"review","venue":"Frontiers in Medicine","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Pyroptosis; Inflammasome; Pyrin domain; Programmed cell death; Necroptosis; Medicine; Retinal; Disease; Apoptosis; Caspase; Retinal degeneration; Cancer research; Bioinformatics; Biology; Immunology; Inflammation; Pathology; Ophthalmology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000631862,0.000396442,0.001118608,0.0003188969,0.00006435878,0.000006511027,0.0004551416,0.0002124623,0.0001534576],"category_scores_gemma":[0.0003419572,0.0003464535,0.0002012568,0.0003125471,0.0001025328,0.000003105449,0.0001995588,0.0005813643,0.000005138076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001125607,"about_ca_system_score_gemma":0.0003669462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000221627,"about_ca_topic_score_gemma":0.000001773001,"domain_scores_codex":[0.9977363,0.0002954883,0.0007025693,0.0005809172,0.0002309492,0.0004537631],"domain_scores_gemma":[0.9991751,0.00001916405,0.0002371743,0.00045078,0.00001594656,0.0001018874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003746752,0.0004130978,0.005968208,0.02233052,0.0002170748,0.0009251048,0.0005741939,0.0001214434,0.0002854472,0.00003626198,0.1298844,0.8388695],"study_design_scores_gemma":[0.0006798264,0.0001670491,0.00004015104,0.001766534,0.0001558643,0.000002672517,0.000440235,0.00003158687,0.000005014599,0.00004380358,0.9963067,0.0003605782],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003104179,0.9958446,0.0002520096,0.0000303738,0.001126516,0.0005409324,0.00001899628,0.000008821933,0.001867335],"genre_scores_gemma":[0.0001609664,0.9957883,0.0004201642,0.0001238566,0.0003124536,0.0001688838,0.002323686,0.00006809439,0.0006335373],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8664222,"threshold_uncertainty_score":0.9998987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01866168878048548,"score_gpt":0.2656504680249112,"score_spread":0.2469887792444257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}