{"id":"W4206378464","doi":"10.15252/emmm.202114764","title":"THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer","year":2022,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Engineering and Physical Sciences Research Council; Beatson Institute for Cancer Research; Medical Research Council; Cancer Research UK","keywords":"Reprogramming; Prostate cancer; Lipid metabolism; Cancer research; Metabolism; Prostate; Cancer; Chemistry; Biology; Medicine; Internal medicine; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004461343,0.0002599419,0.0005055593,0.0001536278,0.0000776689,0.000004947369,0.0002164727,0.00006280515,0.0002662003],"category_scores_gemma":[0.000117866,0.0002281319,0.0001280109,0.0004101941,0.000158209,0.000004184785,0.0001283301,0.000146973,9.107256e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007516067,"about_ca_system_score_gemma":0.0002645917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008056732,"about_ca_topic_score_gemma":0.0006159561,"domain_scores_codex":[0.9979236,0.0001779239,0.0005072861,0.000585094,0.0003963964,0.0004097762],"domain_scores_gemma":[0.998925,0.00001548264,0.0002390378,0.000607037,0.0000873133,0.0001261503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006393102,0.0002752989,0.001946654,0.00006685761,0.0001874171,0.00001960514,0.00162404,0.0002120363,0.97259,0.0002682522,0.01230507,0.009865482],"study_design_scores_gemma":[0.002984729,0.0003663144,0.00236251,0.00004045288,0.00008879022,0.00001381726,0.0004640388,0.000008338996,0.05188696,0.00008123026,0.9414692,0.0002336047],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8732688,0.1160081,0.0001036563,0.001792863,0.005282355,0.0009977367,0.0001376106,0.0000311862,0.00237773],"genre_scores_gemma":[0.9832667,0.005513297,0.0004259364,0.0008900014,0.00364888,0.0009257911,0.0005720799,0.00008000161,0.004677319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9291641,"threshold_uncertainty_score":0.9302948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007766876096793124,"score_gpt":0.2626662403369272,"score_spread":0.2548993642401341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}