{"id":"W4206379059","doi":"10.1038/s41591-021-01625-x","title":"Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication","year":2022,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":255,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Deutsche Krebshilfe; Wellcome Trust; Alex's Lemonade Stand Foundation for Childhood Cancer; University of Southern California; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"CD47; Blockade; Calreticulin; Cancer research; Monoclonal antibody; Neuroblastoma; Medicine; Macrophage; Immunotherapy; Tumor microenvironment; Immunology; Cancer; Antibody; Biology; Receptor; Immune system; Internal medicine; Cell culture; Cell biology; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002761062,0.0002180254,0.0004277408,0.000417886,0.0002259374,0.000007016711,0.0001935673,0.00005936997,0.001035939],"category_scores_gemma":[0.0003321054,0.0001394896,0.00004413521,0.000946406,0.0001200526,0.00004368164,0.0001021533,0.001132391,0.0000600797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000182797,"about_ca_system_score_gemma":0.0001900058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004369764,"about_ca_topic_score_gemma":0.00001570863,"domain_scores_codex":[0.9973845,0.00009077082,0.0002203223,0.0004540397,0.001423815,0.0004265561],"domain_scores_gemma":[0.9986849,0.0001229964,0.00007944641,0.0004536854,0.0001306327,0.0005282707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01339195,0.003688258,0.06979351,0.0006899667,0.001822467,0.03017308,0.003562249,0.0002628503,0.5292164,0.00162853,0.3188912,0.02687954],"study_design_scores_gemma":[0.03106533,0.02776248,0.3044361,0.0007851262,0.0009776714,0.006064527,0.001156823,0.0003492812,0.09779056,0.0002626744,0.5285005,0.0008489585],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9511656,0.001460664,0.00002140356,0.04327749,0.0003218629,0.0008755765,0.00002676142,0.0001358052,0.002714834],"genre_scores_gemma":[0.9902234,0.00004617115,0.0004003325,0.006019255,0.000508023,0.0001912005,0.0001349749,0.00004524559,0.002431388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4314258,"threshold_uncertainty_score":0.9998773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006035995999071824,"score_gpt":0.2871763778405188,"score_spread":0.281140381841447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}