{"id":"W4206379059","doi":"10.1038/s41591-021-01625-x","title":"Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication","year":2022,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":255,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Deutsche Krebshilfe; Wellcome Trust; Alex's Lemonade Stand Foundation for Childhood Cancer; University of Southern California; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"CD47; Blockade; Calreticulin; Cancer research; Monoclonal antibody; Neuroblastoma; Medicine; Macrophage; Immunotherapy; Tumor microenvironment; Immunology; Cancer; Antibody; Biology; Receptor; Immune system; Internal medicine; Cell culture; Cell biology; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002078682,0.0005245651,0.0005268551,0.0003706469,0.0002250547,0.0005184613,0.0003093347,0.0004934088,0.003638404],"category_scores_gemma":[0.0001097139,0.000168007,0.0004820224,0.0002780904,0.0002790768,0.0003367598,0.0003261406,0.001288081,0.0008253154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004579146,"about_ca_system_score_gemma":0.0007162225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009711666,"about_ca_topic_score_gemma":0.002984948,"domain_scores_codex":[0.9997895,0.00003326872,0.000009845682,0.00002168441,0.00003675484,0.0001089695],"domain_scores_gemma":[0.9999346,0.0000118242,0.00000923774,0.000009410474,0.000004834465,0.00003018044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005277753,0.002293854,0.0007641747,0.0002606612,0.0001231515,0.0002430156,0.00005378582,0.00118059,0.9613183,0.001367696,0.004255022,0.02286207],"study_design_scores_gemma":[0.0011825,0.007962035,0.006474144,0.00002360504,0.00009566107,0.0007073689,0.0001154052,0.00284004,0.9596043,0.000362089,0.02061037,0.00002255556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815709,0.002885431,0.001538553,0.0007424389,0.0003762609,0.0001589037,0.001107623,0.0003576183,0.0112623],"genre_scores_gemma":[0.9915397,0.001356978,0.001192464,0.0001878244,0.00005774345,0.0001180813,0.0008591561,0.00003195887,0.004656016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003638404,"threshold_uncertainty_score":0.01217175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006035995999071824,"score_gpt":0.2871763778405188,"score_spread":0.281140381841447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}