{"id":"W4206389320","doi":"10.3389/fnagi.2021.802582","title":"GABAA Receptors in Astrocytes Are Targets for Commonly Used Intravenous and Inhalational General Anesthetic Drugs","year":2022,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Anesthesia and Neurotoxicity Research","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto","funders":"National Research Foundation of Korea; Canadian Institutes of Health Research; National Research Foundation","keywords":"GABAA receptor; Etomidate; Picrotoxin; Anesthetic; Pharmacology; Receptor; Anesthesia; GABA receptor antagonist; Sevoflurane; Medicine; Chemistry; Neuroscience; Bicuculline; Internal medicine; Biology; Propofol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001385233,0.0002981906,0.0003198076,0.0001430233,0.0001776809,0.0002847646,0.000215727,0.0003006831,0.001187405],"category_scores_gemma":[0.0002044699,0.0001099465,0.0003765946,0.0001491149,0.0002063271,0.0001910746,0.0002092112,0.0004109257,0.000320378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002100739,"about_ca_system_score_gemma":0.0002847494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008488702,"about_ca_topic_score_gemma":0.00130452,"domain_scores_codex":[0.9997866,0.00002741942,0.00002622149,0.00004095382,0.00007069488,0.00004816032],"domain_scores_gemma":[0.9998516,0.00001442329,0.00006421509,0.000008552822,0.00004178452,0.00001938751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003116514,0.00002438306,0.002398471,0.0002032557,0.00002503488,0.0002572509,0.0000282053,0.00006104528,0.9895467,0.0001230218,0.0001223446,0.006898632],"study_design_scores_gemma":[0.00007768299,0.001779472,0.1169512,0.0001553219,0.0003177029,0.004133782,0.0004005744,0.001370649,0.8639298,0.0005557397,0.01030331,0.00002474983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682672,0.01964964,0.0065835,0.0004275926,0.0001272241,0.00005474492,0.000285738,0.00008936953,0.004515048],"genre_scores_gemma":[0.988112,0.007422506,0.002579656,0.0002093703,0.00004148448,0.00004858703,0.000197874,0.00001656619,0.001372086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001187405,"threshold_uncertainty_score":0.003972292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02869580116079762,"score_gpt":0.2716548150307062,"score_spread":0.2429590138699085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}