{"id":"W4206407332","doi":"10.1002/alz.051113","title":"Generation of the AD Informer Set: Chemical tools to facilitate Alzheimer’s disease drug discovery","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"","keywords":"Disease; Drug discovery; Set (abstract data type); Computational biology; Medicine; Alzheimer's disease; Clinical trial; Neuroscience; Bioinformatics; Computer science; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008159594,0.001953978,0.001129883,0.00496435,0.0009091201,0.00324904,0.002088929,0.00176884,0.02109254],"category_scores_gemma":[0.00972578,0.000907558,0.00175178,0.001935942,0.0008367543,0.002308332,0.002559176,0.002673671,0.008207058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002074784,"about_ca_system_score_gemma":0.003765596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00215531,"about_ca_topic_score_gemma":0.002691881,"domain_scores_codex":[0.9964812,0.001153834,0.0002614591,0.0003005693,0.001655777,0.0001471104],"domain_scores_gemma":[0.9928305,0.002496479,0.0007849085,0.001299591,0.002129421,0.0004590956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002069511,0.00125215,0.004045165,0.00275006,0.0004169313,0.0008112541,0.0003920545,0.04590083,0.06593886,0.06946181,0.3550264,0.4519349],"study_design_scores_gemma":[0.0006057047,0.0009449165,0.001353589,0.0004992289,0.0003599935,0.0004542181,0.0000828387,0.05788608,0.08644423,0.03798216,0.8130747,0.0003123153],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.04857907,0.01027666,0.5783637,0.01430281,0.003764216,0.004761434,0.1228253,0.07409032,0.1430365],"genre_scores_gemma":[0.08516816,0.0049014,0.7790483,0.003709409,0.000676072,0.003304236,0.09715015,0.003543244,0.02249904],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02109254,"threshold_uncertainty_score":0.07056153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1276940997013093,"score_gpt":0.3149584142548673,"score_spread":0.187264314553558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}