{"id":"W4206411951","doi":"10.31083/j.jin2004088","title":"Neurofilament light as a biomarker of axonal degeneration in patients with mild cognitive impairment and Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"Journal of Integrative Neuroscience","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Neurofilament; Cerebrospinal fluid; Pathology; Alzheimer's disease; Medicine; Psychology; Neuroscience; Disease; Internal medicine; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001696859,0.0001031804,0.000132772,0.00007718067,0.00003807747,0.00001815085,0.00009642487,0.00003380289,0.000009219775],"category_scores_gemma":[0.000282539,0.00006506787,0.00004826041,0.0001722859,0.0002084619,0.00001186389,0.00006944237,0.0001135266,2.875468e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009093484,"about_ca_system_score_gemma":0.0002918571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001813553,"about_ca_topic_score_gemma":0.000007732153,"domain_scores_codex":[0.999,0.0001834679,0.0002209943,0.0002169345,0.0002482217,0.0001303635],"domain_scores_gemma":[0.9991739,0.00002239472,0.0001555279,0.00007963182,0.0004578109,0.0001107535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001638783,0.0005037326,0.2390213,0.000005526837,0.00002252956,0.0001276221,0.00008661337,0.000005903777,0.7576689,0.00003142129,0.0001344668,0.000753185],"study_design_scores_gemma":[0.001050283,0.001797034,0.4503308,0.00006497096,0.00001949968,0.0000496239,0.0001233849,0.00004275588,0.5463336,0.0000129941,0.0001067222,0.00006834292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985183,0.0007615916,0.0002041706,0.000218446,0.00008725055,0.0001232551,0.00001200778,5.138244e-7,0.00007446434],"genre_scores_gemma":[0.9993916,0.0001805684,0.00009651795,0.0002503045,0.00001786263,0.000003936222,0.00001116488,0.000004876929,0.0000431752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2113353,"threshold_uncertainty_score":0.2653391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01854396155661617,"score_gpt":0.2913021095538782,"score_spread":0.2727581479972621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}