{"id":"W4206411951","doi":"10.31083/j.jin2004088","title":"Neurofilament light as a biomarker of axonal degeneration in patients with mild cognitive impairment and Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"Journal of Integrative Neuroscience","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Neurofilament; Cerebrospinal fluid; Pathology; Alzheimer's disease; Medicine; Psychology; Neuroscience; Disease; Internal medicine; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005715796,0.0004831375,0.0005399009,0.001223284,0.0004435951,0.0005258835,0.0002907548,0.0004650076,0.0007755462],"category_scores_gemma":[0.002007829,0.0002443581,0.0003538346,0.0006544583,0.0002695773,0.0003492646,0.0004177339,0.0004538393,0.0001683308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003173172,"about_ca_system_score_gemma":0.000221813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003831313,"about_ca_topic_score_gemma":0.004350205,"domain_scores_codex":[0.9997336,0.00006651389,0.00003687461,0.00005914216,0.0000580071,0.00004583989],"domain_scores_gemma":[0.9990201,0.0002008776,0.000435082,0.00004413694,0.0001230749,0.0001768705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005051057,0.00005274925,0.9970559,0.00001172937,0.00008931781,0.0000967404,0.00007212147,0.00003838929,0.0003479039,0.000008149376,0.00004746226,0.001674473],"study_design_scores_gemma":[0.00000903577,0.0001235837,0.9992884,0.000003102233,0.00002809417,0.0001969932,0.00005994171,0.0001475487,0.00006148075,0.00001955867,0.00005919869,0.00000305637],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994975,0.0002662877,0.00002836996,0.00001409051,0.000003664491,0.000004012569,0.00004516354,0.000002185896,0.0001387418],"genre_scores_gemma":[0.999667,0.00005802282,0.00006838272,0.00001302635,0.000007085627,0.000004390935,0.00008906684,5.465606e-7,0.00009243485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003831313,"threshold_uncertainty_score":0.00761807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01854396155661617,"score_gpt":0.2913021095538782,"score_spread":0.2727581479972621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}