{"id":"W4206417025","doi":"10.1021/acs.orglett.1c04266","title":"Atroposelective Desymmetrization of Resorcinol-Bearing Quinazolinones via Cu-Catalyzed C–O Bond Formation","year":2022,"lang":"en","type":"article","venue":"Organic Letters","topic":"Axial and Atropisomeric Chirality Synthesis","field":"Chemistry","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Chemistry; Desymmetrization; Resorcinol; Catalysis; Enantioselective synthesis; Ligand (biochemistry); Combinatorial chemistry; Stereochemistry; Organic chemistry; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001030722,0.0001331199,0.0002037087,0.00009827628,0.0002458326,0.00001561764,0.0002181957,0.00003658994,0.0008821705],"category_scores_gemma":[0.0000620256,0.0001426762,0.00009084788,0.0004869023,0.00004255683,0.0001850488,0.0001484063,0.0001756975,0.00001735597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002854566,"about_ca_system_score_gemma":0.00002792157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002423695,"about_ca_topic_score_gemma":0.00001103768,"domain_scores_codex":[0.9989067,0.00003462638,0.0003114785,0.0002158227,0.0003146004,0.0002168177],"domain_scores_gemma":[0.9993831,0.00006560641,0.0002439434,0.0002369144,0.00003149784,0.00003891824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004862288,0.00004918949,0.002930125,0.00006831002,0.00003773221,0.000003155846,0.0007625563,0.00002567282,0.9931,0.00008591346,0.000275932,0.002612763],"study_design_scores_gemma":[0.0004486414,0.00002167084,0.001478504,0.00001037497,0.00004952139,0.00002128972,0.0005676202,0.000356556,0.996319,0.0001498899,0.0003919745,0.0001849512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926105,0.00005308393,0.005586126,0.001180781,0.00007410389,0.000074274,0.00001832754,0.00007371823,0.0003291053],"genre_scores_gemma":[0.9991689,0.000007100921,0.0003153899,0.0002162416,0.0001092049,0.00001501368,0.00008696378,0.00002781805,0.00005333088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006558456,"threshold_uncertainty_score":0.9659148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008424851637485936,"score_gpt":0.1967833479506804,"score_spread":0.1883584963131944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}