{"id":"W4206417025","doi":"10.1021/acs.orglett.1c04266","title":"Atroposelective Desymmetrization of Resorcinol-Bearing Quinazolinones via Cu-Catalyzed C–O Bond Formation","year":2022,"lang":"en","type":"article","venue":"Organic Letters","topic":"Axial and Atropisomeric Chirality Synthesis","field":"Chemistry","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Chemistry; Desymmetrization; Resorcinol; Catalysis; Enantioselective synthesis; Ligand (biochemistry); Combinatorial chemistry; Stereochemistry; Organic chemistry; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001989144,0.0006205237,0.0001938524,0.0001586294,0.0001150488,0.0001633763,0.0003503798,0.0001995078,0.001075534],"category_scores_gemma":[0.0001470131,0.0001262896,0.0001495615,0.0001368748,0.0001928197,0.0002433386,0.0002434245,0.0004862681,0.0004052315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001938984,"about_ca_system_score_gemma":0.0002262785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005662528,"about_ca_topic_score_gemma":0.001421417,"domain_scores_codex":[0.9998673,0.00002099887,0.000009261782,0.00003071798,0.00002643337,0.00004514462],"domain_scores_gemma":[0.9999282,0.000006068269,0.00003051674,0.000009296008,0.00001182886,0.00001404004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007626721,0.00004779612,0.0001371803,0.0001172606,0.00001114387,0.0004420691,0.00006503813,0.0003733716,0.9879816,0.001153019,0.0003287955,0.009266347],"study_design_scores_gemma":[0.00002534866,0.000214988,0.0003285857,0.000004396761,0.00001043287,0.0003784935,0.00001918341,0.0007937598,0.9930131,0.00009678595,0.005104286,0.00001069126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9296379,0.004006024,0.05146963,0.0003274953,0.0001460889,0.0001977126,0.0004573721,0.0004812405,0.01327666],"genre_scores_gemma":[0.9874238,0.001820955,0.007389156,0.00005169111,0.00001721545,0.00002959173,0.0001644179,0.00002891369,0.003074249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001075534,"threshold_uncertainty_score":0.003598034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008424851637485936,"score_gpt":0.1967833479506804,"score_spread":0.1883584963131944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}