{"id":"W4206446319","doi":"10.1111/acel.13549","title":"Disruption of ER‐mitochondria tethering and signalling in <i>C9orf72</i>‐associated amyotrophic lateral sclerosis and frontotemporal dementia","year":2022,"lang":"en","type":"article","venue":"Aging Cell","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Alzheimer’s Society; Motor Neurone Disease Association; Medical Research Council; National Institute for Health and Care Research; Alzheimer Society","keywords":"C9orf72; Biology; Frontotemporal dementia; Amyotrophic lateral sclerosis; Cell biology; Mitochondrion; Endoplasmic reticulum; Neuroscience; Trinucleotide repeat expansion; Genetics; Dementia; Internal medicine; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004447004,0.0001522879,0.000322592,0.0001703631,0.000153227,0.00003185027,0.00008930244,0.00005686624,0.0001444858],"category_scores_gemma":[0.00002406793,0.0001502998,0.00004865094,0.0002568669,0.0000783198,0.0001230258,0.0002722307,0.0004056839,0.000001574379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001536846,"about_ca_system_score_gemma":0.00003683826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001261639,"about_ca_topic_score_gemma":0.00005553721,"domain_scores_codex":[0.9983835,0.0001664811,0.0003494328,0.0003404858,0.0004013057,0.0003587684],"domain_scores_gemma":[0.9995244,0.00005748107,0.0001223787,0.0001477126,0.00003778041,0.0001103033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001088441,0.0001253557,0.5035474,0.0001016619,0.0000503833,0.00002834487,0.001233328,0.0002608633,0.4932223,0.000006401658,0.00003923436,0.001275872],"study_design_scores_gemma":[0.003199856,0.000359592,0.9845023,0.0002602566,0.00008038074,0.000009070985,0.0002534309,0.008088096,0.002812749,0.0001377944,0.00008945299,0.0002070822],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976534,0.001260745,0.0000474624,0.000459164,0.00007051757,0.0003276774,0.000009320725,0.00003574476,0.0001359477],"genre_scores_gemma":[0.9988125,0.0002239655,0.0005282999,0.00009212401,0.00003610555,0.00003029026,0.00002454722,0.00003345385,0.000218726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4904096,"threshold_uncertainty_score":0.6129048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0230082181907029,"score_gpt":0.2520584589642884,"score_spread":0.2290502407735855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}