{"id":"W4206446319","doi":"10.1111/acel.13549","title":"Disruption of ER‐mitochondria tethering and signalling in <i>C9orf72</i>‐associated amyotrophic lateral sclerosis and frontotemporal dementia","year":2022,"lang":"en","type":"article","venue":"Aging Cell","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Alzheimer’s Society; Motor Neurone Disease Association; Medical Research Council; National Institute for Health and Care Research; Alzheimer Society","keywords":"C9orf72; Biology; Frontotemporal dementia; Amyotrophic lateral sclerosis; Cell biology; Mitochondrion; Endoplasmic reticulum; Neuroscience; Trinucleotide repeat expansion; Genetics; Dementia; Internal medicine; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000945916,0.0002877931,0.0001807023,0.0001514704,0.0001647034,0.000198305,0.0001721924,0.0004275569,0.001064647],"category_scores_gemma":[0.00006622426,0.0001206477,0.0003036837,0.00008991997,0.000279562,0.0001221442,0.0002403008,0.0004013456,0.0003110325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002522567,"about_ca_system_score_gemma":0.000104225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005186365,"about_ca_topic_score_gemma":0.0006620841,"domain_scores_codex":[0.999913,0.00001098138,0.00001086005,0.00001766406,0.0000248337,0.00002277002],"domain_scores_gemma":[0.999951,0.000006137481,0.00002087509,0.00000463375,0.00000359981,0.00001379683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007905793,0.00001604059,0.0002558506,0.00002161509,0.000005742995,0.000280169,0.000008637173,0.00003668116,0.998763,0.0000478163,0.00003323631,0.0004521605],"study_design_scores_gemma":[0.00004055213,0.0005471094,0.02724893,0.00001142152,0.00004156903,0.003691677,0.00005920909,0.0009869171,0.9643933,0.0001627723,0.002806845,0.000009702801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968478,0.0007835876,0.001012241,0.00006991607,0.00002428393,0.00001479437,0.0002732888,0.00003700453,0.0009370699],"genre_scores_gemma":[0.9983283,0.0002434,0.0003969257,0.00004513574,0.000003589639,0.00001527244,0.0002305466,0.000006496291,0.0007304301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001064647,"threshold_uncertainty_score":0.003561616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0230082181907029,"score_gpt":0.2520584589642884,"score_spread":0.2290502407735855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}