{"id":"W4206450911","doi":"10.3390/cancers14020386","title":"Differential Gene Expression Profiles between N-Terminal Domain and Ligand-Binding Domain Inhibitors of Androgen Receptor Reveal Ralaniten Induction of Metallothionein by a Mechanism Dependent on MTF1","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; National Institutes of Health; University of British Columbia","keywords":"Androgen receptor; Metallothionein; Domain (mathematical analysis); Terminal (telecommunication); Mechanism (biology); Cell biology; Ligand (biochemistry); Gene; Chemistry; Gene expression; RNF4; Receptor; Biology; Genetics; Biochemistry; Physics; Transcription factor; Computer science; Zinc finger","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009859711,0.0001714641,0.0004255719,0.000382544,0.0001251072,0.0002922631,0.00009791995,0.0002450176,0.001518063],"category_scores_gemma":[0.0001545329,0.0001214078,0.0003865595,0.0003916176,0.0001721162,0.0001597501,0.0001163869,0.0004402106,0.0003492663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001918843,"about_ca_system_score_gemma":0.0001750078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006888214,"about_ca_topic_score_gemma":0.001111215,"domain_scores_codex":[0.9997708,0.00001717664,0.00001776849,0.00006871237,0.00005512371,0.00007041587],"domain_scores_gemma":[0.9998388,0.00004202272,0.00003752614,0.00001643494,0.00002334633,0.00004173476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001981934,0.00001942658,0.0006836604,0.00001447437,0.000004812388,0.00001510717,0.00001127481,0.00002245745,0.9982706,0.00001977685,0.00002243526,0.0007178803],"study_design_scores_gemma":[0.00002189868,0.001236281,0.1358531,0.000005757032,0.00004218393,0.0003062501,0.0001542371,0.001279761,0.858097,0.00008054965,0.002909738,0.00001328308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927269,0.001343472,0.001840096,0.00007379,0.00002741674,0.0000309695,0.002598118,0.00007620252,0.001282897],"genre_scores_gemma":[0.9864639,0.0007575401,0.002857513,0.0001572704,0.00001807929,0.0001279306,0.004041607,0.00003218568,0.0055439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001518063,"threshold_uncertainty_score":0.005078435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02114181641118654,"score_gpt":0.2802541078661946,"score_spread":0.259112291455008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}