{"id":"W4206458189","doi":"10.1101/2021.12.18.21267994","title":"Vascular risk burden is a key player in the early progression of Alzheimer’s disease","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; Eisai; Genentech; IXICO; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Northern California Institute for Research and Education; McGill University; F. Hoffmann-La Roche; University of Southern California; Pfizer; Biogen; BioClinica; Novartis Pharmaceuticals Corporation; National Alliance for Research on Schizophrenia and Depression; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Medicine; Cognitive decline; Disease; Neurodegeneration; Pathophysiology; Internal medicine; Risk factor; Stroke (engine); Alzheimer's disease; Context (archaeology); Vascular dementia; Dementia; Cardiology; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001283046,0.000252695,0.0004675345,0.0002086634,0.00005370935,0.00006585406,0.0003372726,0.0001566349,0.0006426546],"category_scores_gemma":[0.0003044359,0.0001619179,0.0003942579,0.0002816596,0.0001276131,0.00004675604,0.0005482471,0.0009809404,0.00003368666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002529985,"about_ca_system_score_gemma":0.0003932966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004793332,"about_ca_topic_score_gemma":0.00001005185,"domain_scores_codex":[0.9967268,0.0005732079,0.0004195017,0.0005533621,0.001369769,0.0003573678],"domain_scores_gemma":[0.9983521,0.00008019948,0.0001838143,0.0009040198,0.0002798272,0.0002000191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002037556,0.0005393017,0.983642,0.0003967548,0.0005018975,0.0006224862,0.003089017,0.000003797357,0.0003351799,0.000005871495,0.0002194869,0.01044044],"study_design_scores_gemma":[0.001131487,0.0001943563,0.9921776,0.001324634,0.0009941494,0.00000308028,0.0004545795,0.000211784,0.002082264,0.0001489601,0.001124171,0.0001529286],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877059,0.007710896,0.00005888606,0.001701838,0.0001073635,0.001637011,0.00003023982,0.00002002377,0.001027817],"genre_scores_gemma":[0.9975961,0.001247877,0.0001676774,0.0001785461,0.0001641207,0.0003753893,0.00009253263,0.00003029024,0.0001474685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01028751,"threshold_uncertainty_score":0.7036617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03199521107575794,"score_gpt":0.3429104082708941,"score_spread":0.3109151971951362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}