{"id":"W4206488373","doi":"10.1200/jco.2022.40.4_suppl.201","title":"Antitumor activity and safety of dostarlimab monotherapy in patients with mismatch repair deficient non-endometrial solid tumors: A post-hoc subgroup analysis of patients with colorectal cancer.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Kelowna General Hospital","funders":"","keywords":"Medicine; Irinotecan; Internal medicine; Endometrial cancer; Oncology; Colorectal cancer; Regimen; Clinical endpoint; Response Evaluation Criteria in Solid Tumors; Oxaliplatin; Discontinuation; Cohort; Cancer; Progressive disease; Clinical trial; Surgery; Phases of clinical research; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001755381,0.0007660799,0.001887047,0.0005503073,0.000284048,0.0006972586,0.0003952307,0.0005270535,0.002243291],"category_scores_gemma":[0.00162709,0.000233191,0.003995148,0.0003787234,0.0002845782,0.0004059579,0.000431813,0.0007558903,0.0002764601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005949813,"about_ca_system_score_gemma":0.0008969863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006753564,"about_ca_topic_score_gemma":0.001653631,"domain_scores_codex":[0.9991822,0.0003113234,0.00008639912,0.0001721591,0.00009160382,0.0001563777],"domain_scores_gemma":[0.9991865,0.0002920603,0.0001650253,0.0001317689,0.00007374117,0.0001509487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7261053,0.003118932,0.1957293,0.0008199951,0.01935514,0.000575074,0.0002788183,0.00169311,0.01692401,0.0001165245,0.002607115,0.03267662],"study_design_scores_gemma":[0.1149193,0.2075567,0.6158064,0.0001019644,0.03320362,0.001602706,0.0007084383,0.008292718,0.0083834,0.0005745494,0.008721406,0.0001288444],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967405,0.001064152,0.0002672974,0.00007940079,0.00005082832,0.0004232193,0.0008905833,0.00001467466,0.0004692162],"genre_scores_gemma":[0.9968024,0.0002132374,0.0002874457,0.0001287496,0.00007181128,0.0004398442,0.001557071,0.000008980139,0.0004904467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002243291,"threshold_uncertainty_score":0.009283483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02379175296422827,"score_gpt":0.3612927453165167,"score_spread":0.3375009923522884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}