{"id":"W4206515520","doi":"10.1039/d1md00228g","title":"Target 2035 – update on the quest for a probe for every protein","year":2021,"lang":"en","type":"editorial","venue":"RSC Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Princess Margaret Cancer Centre; Montreal Neurological Institute and Hospital; Structural Genomics Consortium; University of Toronto","funders":"Genentech; Generalitat de Catalunya; National Institute for Health and Care Research; Cancer Research UK; Ontario Genomics Institute; Mark Foundation For Cancer Research; Wellcome Trust; McGill University; Royal Marsden NHS Foundation Trust; Pfizer; European Commission; Chordoma Foundation; Ontario Genomics; Genome Canada; National Cancer Institute; Seventh Framework Programme; European Federation of Pharmaceutical Industries and Associations; Agència per a la Competitivitat de l’Empresa; European Molecular Biology Laboratory; Merck KGaA; Innovative Medicines Initiative; Wellcome","keywords":"Human proteome project; Proteome; Human genome; Computational biology; Human proteins; Biology; Genome; Proteomics; Bioinformatics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008849459,0.002562829,0.0021363,0.002493431,0.002246146,0.006420067,0.004823645,0.01714549,0.01029611],"category_scores_gemma":[0.01536974,0.0009872185,0.002285517,0.001440802,0.002543937,0.005014791,0.001812554,0.02446801,0.01351473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003884437,"about_ca_system_score_gemma":0.003644974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001268949,"about_ca_topic_score_gemma":0.003012131,"domain_scores_codex":[0.9946868,0.0006282897,0.0006231234,0.0005965207,0.003079257,0.000385904],"domain_scores_gemma":[0.9880227,0.004277518,0.0006915259,0.0002914127,0.004611509,0.002105373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005100854,0.00002287105,0.0000167918,0.0002583436,0.00001447966,0.0001409326,0.0000129281,0.00003668573,0.000206556,0.001011274,0.9888916,0.009336501],"study_design_scores_gemma":[0.00002895007,0.00004121402,0.00008841159,0.0001306247,0.00001891172,0.0002231732,0.00001127502,0.0001087915,0.0001688217,0.0008444044,0.9983249,0.00001039502],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.0001020923,0.01975717,0.0005231405,0.05614605,0.9173276,0.00005044572,0.0001278451,0.0002317765,0.005733778],"genre_scores_gemma":[0.0009782214,0.01739037,0.0005049027,0.08114934,0.873354,0.00006868008,0.0001506221,0.0001147188,0.02628917],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.01714549,"threshold_uncertainty_score":0.04680097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008704604635494018,"score_gpt":0.2583175481975418,"score_spread":0.2496129435620478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}