{"id":"W4206532782","doi":"10.3390/pharmaceutics14010172","title":"Development and Evaluation of an In Silico Dermal Absorption Model Relevant for Children","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Neonatal skin health care","field":"Health Professions","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Physiologically based pharmacokinetic modelling; Medicine; Buprenorphine; Pharmacokinetics; Absorption (acoustics); Pharmacology; Internal medicine; Opioid; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002653215,0.00008465494,0.0001366064,0.0001086281,0.0004108406,0.0000016601,0.00009421873,0.00005055005,0.00008220704],"category_scores_gemma":[0.00007180836,0.00009434262,0.000014695,0.0001195773,0.00001511065,0.00008581285,0.0001346399,0.0003581676,0.000002325597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005255886,"about_ca_system_score_gemma":0.0006908371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004010049,"about_ca_topic_score_gemma":0.0001112823,"domain_scores_codex":[0.9981916,0.0004016051,0.0004688199,0.0001988555,0.0004524997,0.0002866483],"domain_scores_gemma":[0.9993105,0.0001422194,0.0001692366,0.0001201696,0.0001668054,0.00009110347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001351715,0.0007435302,0.125372,0.002116443,0.00007179148,0.000002759585,0.06619145,0.1854732,0.01461796,0.00179766,0.0008670799,0.6013944],"study_design_scores_gemma":[0.003811906,0.00004661436,0.04733037,0.00003692607,0.00005050085,0.000003223038,0.001457561,0.9403697,0.002143995,0.0009495236,0.003653388,0.0001462505],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963341,0.0004847783,0.0001787672,0.0002733273,0.0001997499,0.002319937,0.0001119427,0.00002294349,0.0000745022],"genre_scores_gemma":[0.9922807,0.00003558703,0.005731206,0.0006384391,0.00004493079,0.001028787,0.0001946442,0.00002073827,0.00002495304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7548966,"threshold_uncertainty_score":0.384718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2307806036766046,"score_gpt":0.5139720410480842,"score_spread":0.2831914373714797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}