{"id":"W4206532782","doi":"10.3390/pharmaceutics14010172","title":"Development and Evaluation of an In Silico Dermal Absorption Model Relevant for Children","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Neonatal skin health care","field":"Health Professions","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Physiologically based pharmacokinetic modelling; Medicine; Buprenorphine; Pharmacokinetics; Absorption (acoustics); Pharmacology; Internal medicine; Opioid; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004845545,0.0004844269,0.0005060635,0.0002902472,0.000258473,0.0006428944,0.0008767045,0.0008405173,0.001937858],"category_scores_gemma":[0.001025631,0.0003269696,0.001076383,0.0003032352,0.0001688871,0.0004455776,0.0004831637,0.0006968922,0.0004877736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006625228,"about_ca_system_score_gemma":0.001318107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009025396,"about_ca_topic_score_gemma":0.006355076,"domain_scores_codex":[0.9998487,0.00004545994,0.00001242017,0.00003096813,0.00004583668,0.00001648829],"domain_scores_gemma":[0.9996337,0.0001999508,0.00003750617,0.00002099482,0.00009130438,0.00001658845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001378113,0.0001003241,0.005590463,0.0004152956,0.00006446,0.000341804,0.0001178143,0.9484692,0.01919642,0.002987887,0.001358125,0.02122041],"study_design_scores_gemma":[0.00002048319,0.0001541755,0.0012706,0.00004371677,0.00006035728,0.0001355853,0.00004670205,0.9828961,0.008849899,0.0007357697,0.005762912,0.00002366187],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3789883,0.001947942,0.5920299,0.0006101711,0.0001800895,0.0005646648,0.00414211,0.001144812,0.02039196],"genre_scores_gemma":[0.8151193,0.002908164,0.17051,0.0001901362,0.00003127421,0.0008144823,0.002464591,0.0002454932,0.007716522],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.009025396,"threshold_uncertainty_score":0.01794571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2307806036766046,"score_gpt":0.5139720410480842,"score_spread":0.2831914373714797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}