{"id":"W4206564986","doi":"10.3389/fmolb.2021.794646","title":"Matrin3: Disorder and ALS Pathogenesis","year":2022,"lang":"en","type":"review","venue":"Frontiers in Molecular Biosciences","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Western University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; ALS Society of Canada","keywords":"RNA-binding protein; Biology; RNA splicing; RNA; Neurodegeneration; Protein aggregation; Ubiquitin; Amyotrophic lateral sclerosis; Cell biology; Alternative splicing; Genetics; Gene; Messenger RNA; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000293169,0.0006527549,0.0008326814,0.001986656,0.0002048734,0.0007257748,0.0005851561,0.0008566035,0.00287857],"category_scores_gemma":[0.0004399381,0.0001504612,0.0002968642,0.001893659,0.0003090963,0.0008467101,0.0005156182,0.001055558,0.001613158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004944418,"about_ca_system_score_gemma":0.0007663235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009843281,"about_ca_topic_score_gemma":0.001491981,"domain_scores_codex":[0.9998907,0.00001722161,0.00002175365,0.00002232002,0.00003595249,0.00001191934],"domain_scores_gemma":[0.9998665,0.0000490167,0.00002466332,0.00000369591,0.00003900989,0.00001717237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000109868,0.00004016757,0.0003013596,0.01361289,0.00008513341,0.0003532362,0.0000478613,0.0002454911,0.00144902,0.002786658,0.03212802,0.9488403],"study_design_scores_gemma":[0.00001937557,0.00006909527,0.001642023,0.003522803,0.0001561178,0.003930421,0.0000472213,0.00009983641,0.0004872199,0.001850921,0.9881578,0.00001720783],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001278569,0.9988227,0.00006107993,0.0002023004,0.0001095242,0.000002217631,0.00001526881,0.000007581771,0.0006513784],"genre_scores_gemma":[0.001220335,0.9976466,0.0001247135,0.0002147393,0.0001682245,0.00000444666,0.00004357297,0.000001508727,0.0005758597],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00287857,"threshold_uncertainty_score":0.009629786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03648807473385233,"score_gpt":0.3387317346179251,"score_spread":0.3022436598840727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}