{"id":"W4206572489","doi":"10.1016/j.cell.2021.12.041","title":"Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration","year":2022,"lang":"en","type":"article","venue":"Cell","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":334,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; Tau Consortium; National Institutes of Health; Arizona Biomedical Research Commission; Arizona Department of Health Services; Fundación Ramón Areces; JPB Foundation; Michael J. Fox Foundation for Parkinson's Research","keywords":"Biology; Interactome; Neurodegeneration; Neuroscience; Computational biology; Genetics; Disease; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002968703,0.00007963939,0.0001082365,0.00007261504,0.0001341378,0.00002260973,0.00003264898,0.00001534226,0.0001535703],"category_scores_gemma":[0.00005342395,0.00006192611,0.00001668152,0.0002011767,0.00002925343,0.00005781317,0.00004259991,0.00012098,0.00001366296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005835412,"about_ca_system_score_gemma":0.000196665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001019296,"about_ca_topic_score_gemma":0.000007803447,"domain_scores_codex":[0.9992921,0.00005039613,0.00007401906,0.0001794851,0.0002501253,0.0001539138],"domain_scores_gemma":[0.9996194,0.00005018755,0.00003713659,0.0000949249,0.00006778855,0.0001305546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0285187,0.03608999,0.5511449,0.003863492,0.04910358,0.01918623,0.009163351,0.0007893527,0.1922359,0.0002750992,0.1048914,0.004738027],"study_design_scores_gemma":[0.1601389,0.0746827,0.271019,0.001296793,0.01814436,0.002053911,0.006559184,0.01036012,0.4191312,0.001509471,0.03038583,0.004718544],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967904,0.001633979,0.00000640399,0.0002134498,0.00006048578,0.0003545493,0.00004528394,0.000036711,0.0008587353],"genre_scores_gemma":[0.9988057,0.00002793301,0.00004153745,0.0001089747,0.00005289551,0.00009217909,0.0003472968,0.00001590966,0.000507563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2801259,"threshold_uncertainty_score":0.2525274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01682561534183863,"score_gpt":0.2601041249024348,"score_spread":0.2432785095605962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}