{"id":"W4206599897","doi":"10.1038/s41598-021-03945-x","title":"Genome-wide association study identifies tumor anatomical site-specific risk variants for colorectal cancer survival","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital; Memorial University of Newfoundland","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III; National Health and Medical Research Council; World Cancer Research Fund; Medical Research Council; Centers for Disease Control and Prevention; National Institutes of Health; Hellenic Health Foundation; Institut Gustave-Roussy; Mutuelle Générale de l'Education Nationale; Associazione Italiana per la Ricerca sul Cancro; NordForsk; Vetenskapsrådet; Cancerfonden; Institut National de la Santé et de la Recherche Médicale; Fred Hutchinson Cancer Research Center; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Cancer Research UK; World Health Organization; Umeå Universitet; European Commission; Cancer Council Victoria; Deutsche Krebshilfe; University of Pittsburgh; Brigham and Women's Hospital; Bundesministerium für Bildung und Forschung; National Institute on Aging; National Institute for Health and Care Research; American Cancer Society; Centre International de Recherche sur le Cancer; U.S. Department of Health and Human Services","keywords":"Colorectal cancer; Genome-wide association study; Single-nucleotide polymorphism; Proportional hazards model; Oncology; Disease; Medicine; Internal medicine; Germline; Survival analysis; Cancer; Genotype; Biology; Bioinformatics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001196737,0.000356334,0.0003966172,0.001067447,0.000352963,0.0006281195,0.0003720242,0.0004860911,0.001892705],"category_scores_gemma":[0.002752918,0.0002095989,0.001035672,0.001544567,0.0003750623,0.0002093724,0.0004845252,0.0006157508,0.0001743436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001429504,"about_ca_system_score_gemma":0.0002505214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002785596,"about_ca_topic_score_gemma":0.005053401,"domain_scores_codex":[0.9990429,0.000350648,0.00007866248,0.0003120932,0.0001189188,0.00009658263],"domain_scores_gemma":[0.9976649,0.001051439,0.0006649627,0.0002499275,0.0001526019,0.0002161837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004866451,0.00002546191,0.9874662,0.00004865298,0.001775203,0.0003064649,0.00004490894,0.0004591813,0.005305344,0.0001165494,0.0001980875,0.003767288],"study_design_scores_gemma":[0.00002974178,0.00006931764,0.9968348,0.00001375562,0.0006192238,0.0003747877,0.00005659743,0.0008768431,0.0004583364,0.0002574078,0.0004016581,0.000007623519],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954681,0.002143031,0.001115594,0.0001806866,0.00002944133,0.000005658301,0.0005732407,0.00002431569,0.000459961],"genre_scores_gemma":[0.9991773,0.0002299156,0.0002225664,0.00002822343,0.00001871749,0.000003362473,0.0002348215,0.000005078127,0.00008008417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002785596,"threshold_uncertainty_score":0.006331742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0250465284231614,"score_gpt":0.2911471663674546,"score_spread":0.2661006379442932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}