{"id":"W4206601791","doi":"10.1002/ppap.202100206","title":"A novel 3D in vitro tissue model for bone‐metastasized breast cancer: A preclinical tool in drug discovery and testing","year":2022,"lang":"en","type":"article","venue":"Plasma Processes and Polymers","topic":"Bone health and treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Polytechnique Montréal","funders":"Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Breast cancer; Doxorubicin; Cancer research; Tumor microenvironment; Cancer; Bone metastasis; In vitro; Medicine; Biomedical engineering; Chemistry; Tumor cells; Chemotherapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003756294,0.0006449472,0.0003206258,0.0005288994,0.0002531153,0.0004761433,0.0005702592,0.0008058199,0.001587746],"category_scores_gemma":[0.0001908659,0.0003726039,0.0005176994,0.0002997818,0.0003707105,0.000308618,0.0003551209,0.0007450907,0.0006971283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003751098,"about_ca_system_score_gemma":0.0004539531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00162124,"about_ca_topic_score_gemma":0.002549106,"domain_scores_codex":[0.9997925,0.00003971055,0.00001707112,0.00004527326,0.00008029758,0.00002510918],"domain_scores_gemma":[0.999699,0.0000978519,0.00006057862,0.000060971,0.00003515771,0.00004655456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003869646,0.00007456946,0.0001694584,0.0000758988,0.000008573906,0.0001530081,0.00002141632,0.002718183,0.9944887,0.0004465881,0.0001866803,0.00161823],"study_design_scores_gemma":[0.00003698921,0.0005149619,0.001984172,0.00001794138,0.00005589866,0.0006266228,0.00003493612,0.02658333,0.9587595,0.0003861954,0.0109694,0.00002996872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5901992,0.004739353,0.3851625,0.0007154801,0.0003774551,0.0006534593,0.00596851,0.001675103,0.01050889],"genre_scores_gemma":[0.8516747,0.002506977,0.1378964,0.0002261562,0.00003578109,0.0008496662,0.001859082,0.0001568626,0.004794404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00162124,"threshold_uncertainty_score":0.005311549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03919552638312683,"score_gpt":0.3268913509722108,"score_spread":0.2876958245890839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}