{"id":"W4206602596","doi":"10.1038/s41598-021-03958-6","title":"DNA binding by the antimalarial compound artemisinin","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds Wetenschappelijk Onderzoek; Vlaamse regering; York University","keywords":"Artemisinin; Malaria; Plasmodium falciparum; Computational biology; DNA; Computer science; Virology; Biology; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001724497,0.0002488578,0.0001824805,0.0001355418,0.0002039508,0.0002517303,0.0002789103,0.0004640975,0.001335007],"category_scores_gemma":[0.0003393089,0.0001581944,0.0001537174,0.0001112709,0.0002606023,0.0002027357,0.0002032261,0.0006050547,0.0004420137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002881297,"about_ca_system_score_gemma":0.0001422534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005865026,"about_ca_topic_score_gemma":0.0008972612,"domain_scores_codex":[0.9997188,0.00006586384,0.000009332021,0.00006110236,0.000108707,0.00003624458],"domain_scores_gemma":[0.9998912,0.00004106809,0.00002515422,0.000009355981,0.00001537981,0.00001786091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004039819,0.0000123335,0.000137139,0.00003034519,0.000004428108,0.00002467091,0.0000170282,0.0001344276,0.9974574,0.000235176,0.00006047271,0.00184611],"study_design_scores_gemma":[0.000005059862,0.0001533238,0.0009529445,0.000003302742,0.000003129465,0.0001073402,0.00001123353,0.001558564,0.9948224,0.0000793799,0.002298797,0.000004597787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9668743,0.006217755,0.01765601,0.0003538559,0.00009803895,0.00003687951,0.0001663339,0.0001912424,0.008405469],"genre_scores_gemma":[0.9891985,0.001367485,0.005623416,0.0001976825,0.00001962555,0.00001909659,0.0001802958,0.00001213043,0.003381755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001335007,"threshold_uncertainty_score":0.004465997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01593209639923225,"score_gpt":0.2541505134831981,"score_spread":0.2382184170839659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}