{"id":"W4206610486","doi":"10.1007/s10072-022-05867-6","title":"Perampanel for amyotrophic lateral sclerosis: A systematic review and meta-analysis","year":2022,"lang":"en","type":"review","venue":"Neurological Sciences","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Perampanel; Medicine; Amyotrophic lateral sclerosis; Somnolence; MedDRA; Adverse effect; Epilepsy; C9orf72; Psychology; Internal medicine; Disease; Psychiatry; Frontotemporal dementia; Dementia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005972984,0.00259565,0.01574776,0.003768234,0.0005752082,0.002587405,0.0019673,0.002706059,0.00560376],"category_scores_gemma":[0.01312535,0.001591148,0.02374068,0.004536022,0.0008247025,0.002020617,0.001869621,0.002355883,0.000415855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002239005,"about_ca_system_score_gemma":0.002647645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00714054,"about_ca_topic_score_gemma":0.02699773,"domain_scores_codex":[0.996039,0.001683589,0.001087071,0.0004940137,0.000458615,0.0002377809],"domain_scores_gemma":[0.9949773,0.003132265,0.001258333,0.0001776462,0.0003295626,0.0001248536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00442159,0.00006409415,0.002294773,0.4468782,0.5268362,0.0001638338,0.0001276344,0.0003939926,0.0003814329,0.0001360252,0.0008066233,0.01749562],"study_design_scores_gemma":[0.002534298,0.0003325583,0.003075861,0.0265122,0.9649997,0.0001105865,0.00008100631,0.000129137,0.0001019629,0.0001489202,0.001937908,0.00003591895],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005280083,0.993501,0.0002745845,0.0001181178,0.0001327511,0.000179407,0.0002901225,0.00002323612,0.0002006018],"genre_scores_gemma":[0.1738219,0.821517,0.001891183,0.001185276,0.0002052419,0.0004910769,0.0003762079,0.00002861885,0.0004835497],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01574776,"threshold_uncertainty_score":0.03158849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4632613122666231,"score_gpt":0.4293955449181407,"score_spread":0.0338657673484824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}