{"id":"W4206619080","doi":"10.1242/dev.199840","title":"Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment","year":2022,"lang":"en","type":"article","venue":"Development","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Progenitor cell; Progenitor; Cell biology; Trophoblast; Cytotrophoblast; Stem cell; Cellular differentiation; Genetics; Gene; Placenta; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002431519,0.0002082961,0.000294493,0.0001030865,0.0004750912,0.00001636621,0.0001132539,0.00002515123,0.0002026328],"category_scores_gemma":[0.00001341462,0.0002005873,0.00007173064,0.0001616079,0.00002913021,0.00004856236,0.000252807,0.0002470045,0.00003957384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004355589,"about_ca_system_score_gemma":0.000286142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002402309,"about_ca_topic_score_gemma":0.000009090774,"domain_scores_codex":[0.9983453,0.00006636878,0.0003644763,0.0003621601,0.0005020642,0.0003596638],"domain_scores_gemma":[0.9995503,0.00004491389,0.000079304,0.0001788289,0.00005185075,0.00009481163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"qualitative","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005149735,0.01021698,0.0437973,0.003012185,0.00482314,0.001465753,0.358154,0.01995214,0.1969533,0.0003413311,0.2883858,0.06774837],"study_design_scores_gemma":[0.02552985,0.002676686,0.106492,0.001193953,0.0008360684,0.0002580799,0.03978495,0.00963029,0.3515118,0.001197522,0.4562575,0.0046313],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826946,0.006467202,0.002794349,0.0003096798,0.0003528908,0.0006055037,0.0000381565,0.0001272565,0.006610369],"genre_scores_gemma":[0.9897829,0.0002451786,0.002901199,0.0004937862,0.00001826551,0.0005214337,0.0001017286,0.00002579774,0.005909764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3183691,"threshold_uncertainty_score":0.8179711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01724918771136661,"score_gpt":0.2278796975008097,"score_spread":0.2106305097894431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}