{"id":"W4206619080","doi":"10.1242/dev.199840","title":"Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment","year":2022,"lang":"en","type":"article","venue":"Development","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Progenitor cell; Progenitor; Cell biology; Trophoblast; Cytotrophoblast; Stem cell; Cellular differentiation; Genetics; Gene; Placenta; Fetus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001380474,0.0003337337,0.0002893227,0.0005171319,0.000244927,0.0006924595,0.0003336259,0.0004010318,0.001255819],"category_scores_gemma":[0.0005607562,0.0001563451,0.0003858953,0.0005792646,0.0001873476,0.0002491765,0.0002590286,0.0002958589,0.0003245896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005772936,"about_ca_system_score_gemma":0.0007348519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01565837,"about_ca_topic_score_gemma":0.01623576,"domain_scores_codex":[0.999939,0.000008677612,0.000002482917,0.00002308845,0.00001373794,0.00001306428],"domain_scores_gemma":[0.999886,0.00005245554,0.00001738811,0.00001167015,0.00001938203,0.00001302163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0004981175,0.0001078148,0.08044114,0.0003972004,0.0001177906,0.0004717397,0.000530234,0.6579685,0.1863299,0.01008943,0.003628763,0.05941936],"study_design_scores_gemma":[0.000007456389,0.00002553052,0.008614602,0.00001444312,0.00001974623,0.00007837966,0.00008845983,0.9725222,0.01343932,0.002240086,0.002938232,0.00001163112],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8436343,0.0008681437,0.1462676,0.0002382682,0.0000287347,0.00003497758,0.004110422,0.001030075,0.003787436],"genre_scores_gemma":[0.9538284,0.0006331149,0.03989714,0.00003976948,0.000006426927,0.00007222974,0.00376917,0.0001206467,0.001632992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01565837,"threshold_uncertainty_score":0.03113449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01724918771136661,"score_gpt":0.2278796975008097,"score_spread":0.2106305097894431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}