{"id":"W4206654106","doi":"10.1038/s41420-022-00815-x","title":"ZC3H15 promotes gastric cancer progression by targeting the FBXW7/c-Myc pathway","year":2022,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"Fundamental Research Funds for the Central Universities; Natural Science Foundation of Chongqing; National Natural Science Foundation of China","keywords":"Downregulation and upregulation; Gene silencing; Gene knockdown; Zinc finger; Myeloid leukemia; Cancer research; Biology; Carcinogenesis; Cancer; Transcription factor; Cell growth; Cell biology; Chemistry; Cell culture; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009557555,0.0002604344,0.0001992551,0.000227258,0.0001333442,0.0002165971,0.0001586261,0.0002070323,0.0009659146],"category_scores_gemma":[0.00005437963,0.00008553601,0.0002443516,0.0001650566,0.0002472987,0.0001050089,0.0001995938,0.0004107557,0.0002004702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003339585,"about_ca_system_score_gemma":0.0003162243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001466223,"about_ca_topic_score_gemma":0.002503369,"domain_scores_codex":[0.9999362,0.000007608008,0.000004717517,0.00001071115,0.00001498512,0.0000256423],"domain_scores_gemma":[0.9999675,0.000003000979,0.000009133395,0.000002947828,0.000003678188,0.00001366944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004515461,0.00007931478,0.001483665,0.0001122966,0.00002336899,0.0001100221,0.00002526834,0.0002229061,0.9909623,0.0002870224,0.0002763444,0.005965905],"study_design_scores_gemma":[0.0001195711,0.000661039,0.0221613,0.00001317693,0.00006068787,0.0003189989,0.00006844867,0.003271343,0.9671683,0.0001415542,0.006006859,0.000008697659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940165,0.002832264,0.001221496,0.0001239269,0.0000296549,0.00002911401,0.0002641411,0.0001173259,0.001365621],"genre_scores_gemma":[0.9972436,0.0008095776,0.0005371955,0.00006034149,0.000003934373,0.00001749291,0.0002366411,0.000007215008,0.001084017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001466223,"threshold_uncertainty_score":0.003231347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006382867096303138,"score_gpt":0.233958738139782,"score_spread":0.2275758710434788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}