{"id":"W4206662872","doi":"10.1093/stcltm/szab008","title":"Production of Mesenchymal Progenitor Cell-Derived Extracellular Vesicles in Suspension Bioreactors for Use in Articular Cartilage Repair","year":2022,"lang":"en","type":"article","venue":"Stem Cells Translational Medicine","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Mesenchymal stem cell; Chondrogenesis; Cartilage; Cell biology; Progenitor cell; Bioreactor; Bioprocess; In vivo; Biomedical engineering; Articular cartilage repair; Chemistry; Biophysics; Biology; Stem cell; Articular cartilage; Anatomy; Osteoarthritis; Biotechnology; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003480387,0.0003146413,0.0002998709,0.0003011591,0.0001423676,0.0004939194,0.0002125448,0.0003555912,0.0003601807],"category_scores_gemma":[0.0002265462,0.0001261667,0.0003456149,0.0002028618,0.0001712739,0.000318177,0.0003550886,0.0004082523,0.0002739595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002248692,"about_ca_system_score_gemma":0.0002148281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003492673,"about_ca_topic_score_gemma":0.0004852944,"domain_scores_codex":[0.9998011,0.00003670665,0.00002351372,0.00003543518,0.00008121303,0.0000221375],"domain_scores_gemma":[0.999907,0.00001824219,0.00003298267,0.000007902174,0.00001805634,0.00001576752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003168159,0.00001159652,0.0001195224,0.00004412999,0.000004805156,0.00003559446,0.00001298021,0.0002398085,0.9976376,0.0000975085,0.00001547394,0.001749355],"study_design_scores_gemma":[0.000006413819,0.0002220979,0.0008469294,0.00001104087,0.00002022663,0.0001056032,0.00001961115,0.001438,0.9954229,0.00005397437,0.001848134,0.000005181478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9348862,0.003996273,0.05829799,0.0001262182,0.00008053796,0.0002036028,0.0006129568,0.0001868882,0.001609431],"genre_scores_gemma":[0.9708512,0.00195448,0.02462566,0.00004600361,0.00001948426,0.0001294003,0.0006788527,0.00003818899,0.001656789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004939194,"threshold_uncertainty_score":0.001840591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01915152058408381,"score_gpt":0.2445585933754885,"score_spread":0.2254070727914047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}