{"id":"W4206662872","doi":"10.1093/stcltm/szab008","title":"Production of Mesenchymal Progenitor Cell-Derived Extracellular Vesicles in Suspension Bioreactors for Use in Articular Cartilage Repair","year":2022,"lang":"en","type":"article","venue":"Stem Cells Translational Medicine","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Mesenchymal stem cell; Chondrogenesis; Cartilage; Cell biology; Progenitor cell; Bioreactor; Bioprocess; In vivo; Biomedical engineering; Articular cartilage repair; Chemistry; Biophysics; Biology; Stem cell; Articular cartilage; Anatomy; Osteoarthritis; Biotechnology; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006189961,0.0001851885,0.0002560445,0.0001740387,0.0000683978,0.000003856735,0.0001339228,0.00008676805,0.00004118068],"category_scores_gemma":[0.00004650986,0.0001860941,0.0001279368,0.0002722252,0.0001378794,0.00001626231,0.00003607841,0.0001323798,6.325892e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003839513,"about_ca_system_score_gemma":0.0001162496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000029765,"about_ca_topic_score_gemma":0.00006428011,"domain_scores_codex":[0.9980018,0.0002120599,0.0006178485,0.0005082382,0.0004056824,0.0002543848],"domain_scores_gemma":[0.9992601,0.00006696513,0.0001672347,0.0003249914,0.00009909769,0.00008157769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006107906,0.00042112,0.009258139,0.0001512099,0.00001711402,0.00002754327,0.0003969226,0.002388909,0.9863079,0.0000333218,0.0001678225,0.0002192634],"study_design_scores_gemma":[0.001790707,0.0003989455,0.004786201,0.00004898573,0.00005057472,0.000006545856,0.0006059135,0.001068053,0.9896967,0.00005500255,0.001305861,0.0001864665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945385,0.003186862,0.0004657652,0.000219206,0.000304603,0.001208581,0.00004296023,0.00001639969,0.0000171393],"genre_scores_gemma":[0.9977999,0.00003439251,0.001341714,0.00002136661,0.0001528891,0.0001675774,0.0002564776,0.00003470952,0.0001909769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004471937,"threshold_uncertainty_score":0.7588699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01915152058408381,"score_gpt":0.2445585933754885,"score_spread":0.2254070727914047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}