{"id":"W4206667108","doi":"10.1093/brain/awab350","title":"Diagnostic accuracy of cerebrospinal fluid biomarkers in genetic prion diseases","year":2021,"lang":"en","type":"article","venue":"Brain","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; University Health Network","funders":"Creutzfeldt-Jakob Disease Foundation; National Institute on Aging; Instituto de Salud Carlos III; National Health and Medical Research Council; Bundesministerium für Gesundheit; National Institutes of Health; Generalitat de Catalunya; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Robert Koch Institut; Centres de Recerca de Catalunya","keywords":"PRNP; Fatal familial insomnia; Biomarker; Disease; Neurodegeneration; Medicine; Biology; Prion protein; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000664617,0.00009941053,0.0001138595,0.00003537544,0.00002475574,0.00001435528,0.0001204041,0.00006603104,0.00009907378],"category_scores_gemma":[0.001729117,0.0001054816,0.00009385855,0.0001354325,0.00004276801,0.000003275394,0.0001143917,0.00003227877,0.000004948854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001035899,"about_ca_system_score_gemma":0.0001656972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002365871,"about_ca_topic_score_gemma":0.00002514362,"domain_scores_codex":[0.9991711,0.00009207178,0.000200234,0.0002645412,0.00009864243,0.0001733576],"domain_scores_gemma":[0.9994265,0.000105064,0.00006307244,0.000276442,0.00004466798,0.00008424668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000113598,0.0001615521,0.1094803,0.0001140199,0.00007347089,0.00006276488,0.00002560962,0.00009810171,0.8167495,0.00004986162,0.002045896,0.07102534],"study_design_scores_gemma":[0.001145872,0.0001709913,0.7490901,0.0001503169,0.00003693135,0.00002109186,0.00009209391,0.0001081722,0.2355622,0.000395916,0.01294917,0.000277109],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9659395,0.03286993,0.0003814219,0.000481397,0.00006802993,0.0001568964,0.00004724116,0.000005903973,0.00004969655],"genre_scores_gemma":[0.9965006,0.002212321,0.0007323591,0.0002785958,0.0000835729,0.00002492921,0.0001174955,0.00001347898,0.00003672462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6396098,"threshold_uncertainty_score":0.4301416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00646090509466516,"score_gpt":0.254076630943774,"score_spread":0.2476157258491089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}