{"id":"W4206701971","doi":"10.1002/alz.056115","title":"Developing a novel peptide aptamer‐based treatment of Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"In vitro; Neurotoxicity; In vivo; Genetically modified mouse; MTT assay; Aptamer; Pharmacology; Toxicity; PSEN1; Transgene; Amyloid (mycology); Chemistry; Molecular biology; Alzheimer's disease; Presenilin; Medicine; Biology; Disease; Biochemistry; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001114962,0.0003727338,0.0003835279,0.0002544629,0.00011747,0.0002426195,0.0002572271,0.0004184128,0.00121828],"category_scores_gemma":[0.0000797939,0.0001411954,0.0003112164,0.0001296389,0.000122262,0.0002175249,0.000164293,0.000514227,0.0004865704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001498633,"about_ca_system_score_gemma":0.0001288633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002928304,"about_ca_topic_score_gemma":0.0003552042,"domain_scores_codex":[0.999933,0.000007623155,0.000004996294,0.00002104397,0.00001983617,0.00001347675],"domain_scores_gemma":[0.9999741,0.000003946609,0.000004845397,0.000001778328,0.000008547583,0.000006666992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001906317,0.0001773705,0.00009568474,0.0002156355,0.00002290022,0.0001361404,0.00002966132,0.0003254183,0.970645,0.0002315311,0.0005789424,0.02735116],"study_design_scores_gemma":[0.0002743408,0.003717321,0.00163312,0.00003365722,0.0001167445,0.001257683,0.00002470478,0.004163469,0.9576264,0.000291168,0.03083723,0.00002413986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8670127,0.045727,0.06961951,0.0009423002,0.001056881,0.0008689781,0.0007756799,0.0009242834,0.01307252],"genre_scores_gemma":[0.947615,0.01028545,0.02949875,0.0007077061,0.0001346706,0.0004511114,0.0004854499,0.00004439581,0.01077748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00121828,"threshold_uncertainty_score":0.004075587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0823383790655659,"score_gpt":0.3431350395698591,"score_spread":0.2607966605042932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}