{"id":"W4206707498","doi":"10.3389/fmed.2021.826557","title":"Inflammasome Activation in Pulmonary Arterial Hypertension","year":2022,"lang":"en","type":"review","venue":"Frontiers in Medicine","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Canadian Lung Association; AstraZeneca Canada; AstraZeneca","keywords":"Pyroptosis; Inflammasome; Pathogenesis; Immunology; Medicine; Effector; Lung; Lytic cycle; Immune system; Pulmonary hypertension; Inflammation; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003209564,0.0006880052,0.0009413927,0.001803424,0.0002841948,0.0008966638,0.0005144569,0.0009828433,0.003554875],"category_scores_gemma":[0.0003866083,0.0001941593,0.0003671161,0.001553638,0.0003706026,0.00097192,0.0007566928,0.001422253,0.002379875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000400287,"about_ca_system_score_gemma":0.0008115066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004890423,"about_ca_topic_score_gemma":0.0008262171,"domain_scores_codex":[0.999878,0.00002007127,0.00001942993,0.00002205285,0.00004669688,0.00001369716],"domain_scores_gemma":[0.9998714,0.00005086806,0.00002230686,0.000004122076,0.00003456626,0.00001676497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001000717,0.00007064337,0.0001522169,0.01938877,0.000066359,0.0003938405,0.00007995666,0.0002799836,0.003160671,0.004268251,0.03631814,0.9357212],"study_design_scores_gemma":[0.00002288806,0.0001061615,0.000991952,0.003737726,0.00007215217,0.003016292,0.00006019004,0.00008358886,0.0006980059,0.002724768,0.9884661,0.0000201413],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009264267,0.9985148,0.00009793987,0.0001871251,0.0002093668,0.000003732263,0.00001348287,0.00000632788,0.0008745992],"genre_scores_gemma":[0.0006256511,0.9983467,0.0001051098,0.0001316611,0.0001979745,0.000006098089,0.00002492515,0.000001147754,0.0005608022],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003554875,"threshold_uncertainty_score":0.01189226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02307801237829539,"score_gpt":0.2721511839085576,"score_spread":0.2490731715302623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}