{"id":"W4206707498","doi":"10.3389/fmed.2021.826557","title":"Inflammasome Activation in Pulmonary Arterial Hypertension","year":2022,"lang":"en","type":"review","venue":"Frontiers in Medicine","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Canadian Lung Association; AstraZeneca Canada; AstraZeneca","keywords":"Pyroptosis; Inflammasome; Pathogenesis; Immunology; Medicine; Effector; Lung; Lytic cycle; Immune system; Pulmonary hypertension; Inflammation; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004140235,0.0003359337,0.001143945,0.00047819,0.00004769893,0.000005318545,0.000311081,0.0003675567,0.0001289092],"category_scores_gemma":[0.000218717,0.0002921942,0.0001449487,0.0003855053,0.00009739569,0.000006589371,0.0001473097,0.0004525853,0.000003910788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001104577,"about_ca_system_score_gemma":0.000161705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003437242,"about_ca_topic_score_gemma":0.000006901861,"domain_scores_codex":[0.9981209,0.0002274331,0.0006447452,0.0004863877,0.0002084131,0.0003120942],"domain_scores_gemma":[0.9992833,0.00001862454,0.0002162899,0.0004267906,0.00001638446,0.00003865106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001232119,0.00007044271,0.00009705024,0.001251007,0.00006204342,0.00005474115,0.00005866402,0.000004305376,0.001010509,0.000003714171,0.0143468,0.9829175],"study_design_scores_gemma":[0.000725318,0.0001448736,0.00007218148,0.001744311,0.00006437375,0.00001916167,0.0002534891,0.00001023678,0.00002657634,0.0000407719,0.9966078,0.0002909483],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008873335,0.9949076,0.00008655995,0.00007954633,0.00207609,0.0005993525,0.000004516316,0.000008407243,0.001350583],"genre_scores_gemma":[0.0001334519,0.9960134,0.0001086695,0.00014441,0.0005724649,0.0001861509,0.00240333,0.00005305282,0.0003850701],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9826266,"threshold_uncertainty_score":0.999953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02307801237829539,"score_gpt":0.2721511839085576,"score_spread":0.2490731715302623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}