{"id":"W4206716052","doi":"10.1016/j.cbpc.2022.109267","title":"Copper modulates heart mitochondrial H2O2 emission differently during fatty acid and pyruvate oxidation","year":2022,"lang":"en","type":"article","venue":"Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Prince Edward Island","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Palmitoylcarnitine; Mitochondrion; Pyruvate decarboxylation; Electron transport chain; Biochemistry; Pyruvate dehydrogenase complex; Substrate (aquarium); Beta oxidation; Chemistry; Redox; Mitochondrial ROS; Biology; Biophysics; Metabolism; Enzyme; Inorganic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002489214,0.0005144599,0.0005609125,0.0002483586,0.0003890471,0.0004784933,0.0003830919,0.0006340738,0.002164434],"category_scores_gemma":[0.0004020914,0.0003245073,0.0003702641,0.0002097491,0.0008043706,0.0006055061,0.0004178637,0.0005643623,0.0001995207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008492182,"about_ca_system_score_gemma":0.0002978627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001856636,"about_ca_topic_score_gemma":0.002717131,"domain_scores_codex":[0.9997478,0.00005162343,0.0000120966,0.00005993153,0.00002075865,0.0001078086],"domain_scores_gemma":[0.9997446,0.00004472327,0.00005360742,0.00003926329,0.00004604052,0.00007183276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01043323,0.00006369018,0.0008529279,0.00008134283,0.00003348075,0.0001556107,0.0001027676,0.000038798,0.9857195,0.0001692944,0.0001466408,0.002202771],"study_design_scores_gemma":[0.0004100879,0.001435433,0.05586487,0.00003210115,0.0001452302,0.0002662201,0.0004336222,0.001030264,0.9382759,0.0003905607,0.001687144,0.00002854112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960879,0.001333591,0.001155172,0.0001849236,0.0001013826,0.00002081527,0.0001001814,0.00004601351,0.0009700485],"genre_scores_gemma":[0.9963635,0.0003353903,0.0004320009,0.00007251158,0.00003989448,0.00002867852,0.00008983177,0.00001816088,0.002620129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002164434,"threshold_uncertainty_score":0.007240713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02243212196043838,"score_gpt":0.2914117157627485,"score_spread":0.2689795938023101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}