{"id":"W4206716689","doi":"10.1126/science.abm0594","title":"CAR T cells produced in vivo to treat cardiac injury","year":2022,"lang":"en","type":"article","venue":"Science","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1241,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute","keywords":"In vivo; Chimeric antigen receptor; Cardiac fibrosis; Fibrosis; Cardiac function curve; Ex vivo; Antigen; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003869208,0.0005097278,0.0003559973,0.0003236342,0.0001569855,0.0003944936,0.0002165253,0.0007118596,0.002898681],"category_scores_gemma":[0.0002425027,0.000165645,0.0003023277,0.0001523739,0.0002567236,0.0002475253,0.000237472,0.001540319,0.0008029394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000179,"about_ca_system_score_gemma":0.0002705073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002612068,"about_ca_topic_score_gemma":0.0002841455,"domain_scores_codex":[0.9997726,0.0000510184,0.00001488974,0.00005244809,0.00005289908,0.00005617497],"domain_scores_gemma":[0.999897,0.00002286403,0.000024642,0.00001438324,0.00001535651,0.00002574116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002342947,0.0003021111,0.0002501726,0.0001742692,0.00002721939,0.0001999992,0.00006948243,0.0002944102,0.9839648,0.001032605,0.0009101196,0.01254061],"study_design_scores_gemma":[0.0002797265,0.00341113,0.0008838041,0.0000320422,0.0001297003,0.001154706,0.00005272492,0.001706535,0.9623747,0.000336099,0.02962886,0.00000996739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8885036,0.01884351,0.07007264,0.002072367,0.001388706,0.0009473208,0.0006865992,0.001717857,0.01576758],"genre_scores_gemma":[0.9741232,0.003580353,0.01291523,0.0006948928,0.0001726338,0.0003776944,0.0006516969,0.00007324455,0.007411098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002898681,"threshold_uncertainty_score":0.00969708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02245622904933814,"score_gpt":0.3354162901594916,"score_spread":0.3129600611101535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}