{"id":"W4206737391","doi":"10.3390/cancers14030503","title":"Chimeric Antigen Receptor T-Cell Therapy in Metastatic Castrate-Resistant Prostate Cancer","year":2022,"lang":"en","type":"review","venue":"Cancers","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Partenariat Canadien Contre Le Cancer; Australian Government; PA Research Foundation","keywords":"Prostate cancer; Medicine; Chimeric antigen receptor; Immunotherapy; Cancer; Clinical trial; Oncology; Targeted therapy; Prostate; Antigen; Internal medicine; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006109175,0.0006560218,0.002425413,0.000578604,0.0001088095,0.00004831997,0.0004158443,0.0001398631,0.04376161],"category_scores_gemma":[0.00002758657,0.0005340598,0.0005899918,0.001802244,0.0001703733,0.00006163096,0.00008218938,0.001349606,0.00008445324],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.007733155,"about_ca_system_score_gemma":0.01147715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00467151,"about_ca_topic_score_gemma":0.0003079803,"domain_scores_codex":[0.9961062,0.0004748862,0.000831916,0.0008938694,0.0008086772,0.0008844521],"domain_scores_gemma":[0.9983274,0.0001819097,0.0003849582,0.000747491,0.00006496201,0.0002932154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004538319,0.00006786556,0.00002658169,0.009338965,0.0005257982,0.0002794984,0.000452494,0.00002724022,0.0007597939,0.000001775248,0.003113838,0.9849523],"study_design_scores_gemma":[0.001647351,0.0005325024,0.000009354068,0.003183868,0.0002401197,0.00002411749,0.000220111,0.000009235891,0.0001041373,0.000002768755,0.9935516,0.0004748877],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001238051,0.9901325,3.784403e-7,0.00005787089,0.0006397645,0.004235738,0.0003982616,0.00005639848,0.003241037],"genre_scores_gemma":[0.00002441622,0.9759189,0.00007561174,0.0001549845,0.0002170098,0.003053225,0.0003722744,0.0002409158,0.01994262],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9904377,"threshold_uncertainty_score":0.9997111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1092525452124946,"score_gpt":0.4015275827211105,"score_spread":0.2922750375086159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}