{"id":"W4206737391","doi":"10.3390/cancers14030503","title":"Chimeric Antigen Receptor T-Cell Therapy in Metastatic Castrate-Resistant Prostate Cancer","year":2022,"lang":"en","type":"review","venue":"Cancers","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Partenariat Canadien Contre Le Cancer; Australian Government; PA Research Foundation","keywords":"Prostate cancer; Medicine; Chimeric antigen receptor; Immunotherapy; Cancer; Clinical trial; Oncology; Targeted therapy; Prostate; Antigen; Internal medicine; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003945258,0.0004932019,0.0009452218,0.001266899,0.0001434759,0.0005016926,0.0005137821,0.0007438018,0.002284192],"category_scores_gemma":[0.0003001636,0.0001606515,0.0004988812,0.001055889,0.0002406578,0.0005090595,0.0003543117,0.001278052,0.001158613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003996786,"about_ca_system_score_gemma":0.0005785393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009889803,"about_ca_topic_score_gemma":0.001760683,"domain_scores_codex":[0.9999,0.00002475889,0.00001006829,0.00001342656,0.00004061695,0.00001117195],"domain_scores_gemma":[0.9999145,0.00004066994,0.00001441961,0.000002542853,0.00001936508,0.000008487955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001453901,0.00009600781,0.00009209816,0.02295722,0.0001288183,0.0001873413,0.00005501064,0.0007060216,0.003353123,0.003861878,0.02685726,0.9415599],"study_design_scores_gemma":[0.00006498976,0.0002726455,0.0006583272,0.00471987,0.0001632246,0.001150568,0.00003565596,0.00018618,0.0009500852,0.00145574,0.9903275,0.00001516051],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001684324,0.9988258,0.00007727952,0.00009505716,0.00008951229,0.000005216793,0.000009435948,0.000006577994,0.0007225978],"genre_scores_gemma":[0.001121773,0.9980111,0.0001083612,0.0001485879,0.00004686987,0.000006708611,0.00002091139,0.000001252551,0.0005346607],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002284192,"threshold_uncertainty_score":0.007641435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1092525452124946,"score_gpt":0.4015275827211105,"score_spread":0.2922750375086159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}