{"id":"W4206737985","doi":"10.1001/jama.288.23.2967","title":"Update: Fatal and Severe Liver Injuries Associated With Rifampin and Pyrazinamide Treatment for Latent Tuberculosis Infection","year":2002,"lang":"en","type":"article","venue":"JAMA","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Health Canada; Centers for Disease Control and Prevention; Washington State University; Kaiser Permanente","keywords":"Medicine; Pyrazinamide; Tuberculosis; Latent tuberculosis; Rifampicin; Internal medicine; Mycobacterium tuberculosis; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001390701,0.001111883,0.002269828,0.003864406,0.0004713145,0.001412983,0.001408693,0.003858219,0.004833202],"category_scores_gemma":[0.005974208,0.0003749366,0.001099844,0.002537403,0.0004475811,0.001279927,0.0006221211,0.002149467,0.003058526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007850193,"about_ca_system_score_gemma":0.001043574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004721144,"about_ca_topic_score_gemma":0.0235201,"domain_scores_codex":[0.9990315,0.000203344,0.0002582002,0.00005509235,0.0003885327,0.00006338255],"domain_scores_gemma":[0.993726,0.002288588,0.001091201,0.0001320569,0.002294314,0.0004679326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0002660149,0.00008220215,0.002678203,0.004495128,0.0001942381,0.001378644,0.0000431743,0.0001597992,0.0002882241,0.0001709111,0.7491291,0.2411144],"study_design_scores_gemma":[0.0001440173,0.0002684109,0.01290513,0.00310714,0.0008186117,0.00495628,0.00008417491,0.0001550873,0.0002067274,0.0001882696,0.977129,0.00003702783],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.004509661,0.8529358,0.00166625,0.03952497,0.06876826,0.0002160616,0.003181607,0.00066507,0.02853242],"genre_scores_gemma":[0.02407383,0.783201,0.002860486,0.0586092,0.1017091,0.0002132492,0.004775657,0.00008715698,0.02447034],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004833202,"threshold_uncertainty_score":0.01616865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09098552226784327,"score_gpt":0.3508745833039286,"score_spread":0.2598890610360853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}