{"id":"W4206739074","doi":"10.1111/apt.16753","title":"Randomised clinical trial: a phase 1b study of GB004, an oral HIF‐1α stabiliser, for treatment of ulcerative colitis","year":2022,"lang":"en","type":"article","venue":"Alimentary Pharmacology & Therapeutics","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Ulcerative colitis; Placebo; Internal medicine; Adverse effect; Gastroenterology; Pharmacodynamics; Dysgeusia; Pharmacokinetics; Nausea; Inflammatory bowel disease; Colitis; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003074202,0.002373108,0.004494454,0.0006056135,0.000564966,0.001490663,0.001503455,0.003293278,0.02080705],"category_scores_gemma":[0.00306112,0.0009155104,0.001584752,0.0007465617,0.001968011,0.001223063,0.0006010939,0.003622648,0.003233631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008471233,"about_ca_system_score_gemma":0.002213408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001136643,"about_ca_topic_score_gemma":0.002093007,"domain_scores_codex":[0.9986712,0.0007901739,0.00005819244,0.0002072818,0.0001047773,0.000168435],"domain_scores_gemma":[0.9985316,0.0003893708,0.000331403,0.0001434603,0.0001158502,0.0004883048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9830563,0.004798965,0.0002381287,0.0007395977,0.0003283097,0.0000642569,0.00003714106,0.0001627255,0.002394089,0.0001222816,0.00119469,0.006863568],"study_design_scores_gemma":[0.9825692,0.01646899,0.0002919992,0.00001286373,0.00005191016,0.00001792072,0.000005163275,0.00007180283,0.00006200556,0.00004854296,0.000395097,0.000004552405],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9217194,0.01270356,0.002510325,0.004421357,0.003215302,0.04146437,0.006632814,0.0005932834,0.006739585],"genre_scores_gemma":[0.8887899,0.009377326,0.007357968,0.007869819,0.002340008,0.05732287,0.006532927,0.0001377768,0.02027124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02080705,"threshold_uncertainty_score":0.06960654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1093511981041874,"score_gpt":0.4477877751399043,"score_spread":0.3384365770357168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}