{"id":"W4206750467","doi":"10.1101/2021.03.08.434228","title":"Sialic acid-Dependent Binding and Viral Entry of SARS-CoV-2","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Glycomics Network; European Commission; University of Alberta","keywords":"Sialic acid; Glycan; Glycolipid; Neuraminidase; Viral entry; Heparan sulfate; Ganglioside; Oligosaccharide; Glycoprotein; N-Acetylneuraminic acid; Plasma protein binding; Biochemistry; Chemistry; Receptor; Biology; Virology; Virus; Cell; Viral replication","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008576643,0.0002304485,0.0001774194,0.0001186467,0.00009358228,0.0002576203,0.0001010101,0.00014988,0.001501267],"category_scores_gemma":[0.0001004906,0.0000903923,0.0001820044,0.00008199162,0.0001464679,0.0001182063,0.0001987737,0.000244916,0.0005593837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002749436,"about_ca_system_score_gemma":0.0001452283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007847071,"about_ca_topic_score_gemma":0.0008230919,"domain_scores_codex":[0.999917,0.00001396969,0.000004739121,0.00001162791,0.00002725735,0.00002535105],"domain_scores_gemma":[0.9999719,0.000006011961,0.000005775601,0.000003682834,0.000003646053,0.000009014571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007402202,0.000007573864,0.0002527897,0.000009924534,0.000002184002,0.00002369693,0.000004634174,0.00004347187,0.9991646,0.00006101778,0.00001514554,0.0003411538],"study_design_scores_gemma":[0.00001020221,0.0001079424,0.01235477,0.00000384721,0.000005318977,0.0002498073,0.00002649416,0.001723832,0.9840857,0.00008466181,0.001342867,0.000004598321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970955,0.0006784135,0.0006520544,0.00003300207,0.000008708933,0.000007658447,0.0001788714,0.00001283647,0.00133298],"genre_scores_gemma":[0.9954302,0.000437922,0.001052627,0.00004386374,0.000004676483,0.000008914212,0.0006384227,0.00001133884,0.002371954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001501267,"threshold_uncertainty_score":0.005022228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03560351697183185,"score_gpt":0.300947007708708,"score_spread":0.2653434907368761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}