{"id":"W4206760173","doi":"10.1016/j.ebiom.2021.103776","title":"Predicting sepsis severity at first clinical presentation: The role of endotypes and mechanistic signatures","year":2022,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":220,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Toronto; Vancouver General Hospital; St. Michael's Hospital; Simon Fraser University; Genome British Columbia","funders":"Canadian Institutes of Health Research; Killam Trusts; University of British Columbia; Canada Research Chairs","keywords":"Sepsis; Triage; Endotype; Immune system; Severity of illness; Severe sepsis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004418083,0.0001130017,0.0003121338,0.00006355943,0.0003063098,0.0000044185,0.00007950969,0.00004082073,0.0009798886],"category_scores_gemma":[0.0002551198,0.00007051481,0.00008034809,0.0001952567,0.000165327,0.00001913815,0.0001982119,0.0001938932,0.000003315154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000670325,"about_ca_system_score_gemma":0.00003484655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001952803,"about_ca_topic_score_gemma":0.00003992635,"domain_scores_codex":[0.9987425,0.00009868908,0.0003487299,0.0002414711,0.0004220854,0.0001465357],"domain_scores_gemma":[0.9986799,0.0007727225,0.0001446871,0.0002494064,0.00005272543,0.0001005852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003464433,0.0005900563,0.9805462,0.00007660806,0.0004048369,0.00005965499,0.001191364,0.00001127388,0.001124308,0.0003867131,0.007047046,0.008215484],"study_design_scores_gemma":[0.004219459,0.002673352,0.9174638,0.0001069833,0.00094439,0.0001786553,0.003136041,0.002480447,0.003849697,0.0009532907,0.06386029,0.0001335814],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98347,0.006811584,0.000005456205,0.007570351,0.0003143854,0.0005254658,0.00005375791,0.00003598279,0.001212985],"genre_scores_gemma":[0.9981274,0.0003034049,0.0001200021,0.0007554538,0.0002516954,0.00009630739,0.00006976973,0.00001309249,0.0002628969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0630824,"threshold_uncertainty_score":0.9999334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04521171926537058,"score_gpt":0.3479374299865433,"score_spread":0.3027257107211727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}