{"id":"W4206760173","doi":"10.1016/j.ebiom.2021.103776","title":"Predicting sepsis severity at first clinical presentation: The role of endotypes and mechanistic signatures","year":2022,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":220,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Toronto; Vancouver General Hospital; St. Michael's Hospital; Simon Fraser University; Genome British Columbia","funders":"Canadian Institutes of Health Research; Killam Trusts; University of British Columbia; Canada Research Chairs","keywords":"Sepsis; Triage; Endotype; Immune system; Severity of illness; Severe sepsis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009796815,0.0003748528,0.0004061625,0.000890125,0.0001676451,0.0007143901,0.000212174,0.0003082279,0.0007802143],"category_scores_gemma":[0.002246569,0.000114476,0.0003382452,0.0006032119,0.0002761763,0.000463987,0.0005716172,0.0005100486,0.0002137652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001850586,"about_ca_system_score_gemma":0.0001871398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003289645,"about_ca_topic_score_gemma":0.0005614619,"domain_scores_codex":[0.9995393,0.0001907464,0.00004708295,0.0001055262,0.000068719,0.00004862749],"domain_scores_gemma":[0.9980853,0.0007086243,0.000711164,0.0001103733,0.0001635389,0.0002211854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003412487,0.00002855707,0.9860203,0.00002707811,0.00005652908,0.00007047279,0.00005293845,0.0005812708,0.003125498,0.00004129564,0.0001027272,0.009552215],"study_design_scores_gemma":[0.000007750858,0.0001162339,0.9921309,0.00002486183,0.00004463894,0.000313215,0.0001581615,0.005604695,0.0008524173,0.0005127888,0.0002250197,0.000009339971],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974184,0.0005199699,0.001282805,0.0001167147,0.000007478354,0.00001441254,0.0002630148,0.000009363512,0.0003677531],"genre_scores_gemma":[0.9982242,0.0002011539,0.001144277,0.00003837655,0.00001604938,0.00001166208,0.0003070688,0.000003912926,0.00005336243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009796815,"threshold_uncertainty_score":0.005181074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04521171926537058,"score_gpt":0.3479374299865433,"score_spread":0.3027257107211727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}