{"id":"W4206783242","doi":"10.3389/fimmu.2021.790258","title":"Cleavage-Mediated Regulation of Myd88 Signaling by Inflammasome-Activated Caspase-1","year":2022,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Research Institute for Microbial Diseases, Osaka University; Universität Duisburg-Essen; Javna Agencija za Raziskovalno Dejavnost RS; Norges Teknisk-Naturvitenskapelige Universitet; McGill University","keywords":"Inflammasome; Cell biology; Signal transduction; Innate immune system; Caspase 1; Cleavage (geology); Chemistry; Biology; Receptor; Inflammation; Immunology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002601683,0.000378044,0.0002163199,0.0001695635,0.0001410163,0.0002589202,0.0002242243,0.0002945637,0.001183766],"category_scores_gemma":[0.0002030872,0.000115863,0.0003552628,0.00009194925,0.000232699,0.0003529689,0.0003558041,0.0007605503,0.0003830297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002223563,"about_ca_system_score_gemma":0.0001170941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000552254,"about_ca_topic_score_gemma":0.00006983134,"domain_scores_codex":[0.9997068,0.00005647443,0.00003416317,0.00006861447,0.00006585562,0.00006801756],"domain_scores_gemma":[0.9998394,0.00002156739,0.00006613212,0.00002706979,0.00002252234,0.00002325003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008234571,0.00001131208,0.0002055246,0.0000435139,0.000003525713,0.0000713322,0.00001110209,0.00003242844,0.9982752,0.0001602005,0.00002522121,0.001078277],"study_design_scores_gemma":[0.00001541598,0.0001343876,0.003004828,0.000006359384,0.000005190996,0.0006282838,0.00001588806,0.0005599755,0.9941777,0.0001204106,0.001327694,0.000003787834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746493,0.005686382,0.01681029,0.0002915139,0.00008888985,0.00006847084,0.0003694519,0.0001477435,0.00188797],"genre_scores_gemma":[0.992081,0.001049793,0.005646368,0.00005966059,0.00001400054,0.00003639797,0.0002543729,0.00001134237,0.0008469992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001183766,"threshold_uncertainty_score":0.003960133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003608420423752101,"score_gpt":0.1909891521717086,"score_spread":0.1873807317479565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}