{"id":"W4206789975","doi":"10.1200/jco.2022.40.4_suppl.240","title":"Nivolumab (NIVO) plus chemotherapy (chemo) versus chemo as first-line (1L) treatment for advanced gastric cancer/gastroesophageal junction cancer/esophageal adenocarcinoma (GC/GEJC/EAC): Expanded efficacy, safety, and subgroup analyses from CheckMate 649.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Internal medicine; Nivolumab; Cancer; Randomized controlled trial; FOLFOX; Oncology; Chemotherapy; Gastroesophageal Junction; Gastroenterology; Adenocarcinoma; Oxaliplatin; Immunotherapy; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002392248,0.001197211,0.002370625,0.0005310359,0.0002121686,0.0008850959,0.0007387358,0.0008984747,0.003295521],"category_scores_gemma":[0.001580282,0.0004105892,0.005888324,0.0004701333,0.0004009788,0.0006226561,0.0005428748,0.00157463,0.0002861848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008280796,"about_ca_system_score_gemma":0.0007399564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009263518,"about_ca_topic_score_gemma":0.003620326,"domain_scores_codex":[0.9991078,0.0005410291,0.00006431871,0.0001109064,0.00005604443,0.0001198066],"domain_scores_gemma":[0.9993315,0.0002656021,0.0001837818,0.00006783878,0.00002799188,0.0001233322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9568101,0.001873261,0.004791801,0.001010526,0.01321722,0.0000654633,0.00004320774,0.001157682,0.002679092,0.00009377614,0.0006621883,0.01759574],"study_design_scores_gemma":[0.649986,0.2212118,0.04589961,0.0003306128,0.06659747,0.0002367586,0.0001675715,0.006716831,0.003646968,0.0008973342,0.004219839,0.00008910336],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858981,0.009425177,0.0005201194,0.000338276,0.0002494642,0.001088337,0.001276894,0.00004918218,0.001154318],"genre_scores_gemma":[0.9941208,0.002092667,0.0005859294,0.0003975106,0.000167495,0.0008092265,0.0008086715,0.00001035802,0.001007405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003295521,"threshold_uncertainty_score":0.01265156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1421870874614978,"score_gpt":0.4644255284061629,"score_spread":0.322238440944665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}