{"id":"W4206800089","doi":"10.3791/63176","title":"Organ Culture System for Assessing the Toxicity of Intraocular Treatment Excipients and Pharmaceuticals","year":2022,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Cataracts; Toxicity; In vivo; Organ culture; In vitro; In vitro toxicology; Lens (geology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002844049,0.001759123,0.001464291,0.00221092,0.001477602,0.001454585,0.001921806,0.001587462,0.01283027],"category_scores_gemma":[0.001207823,0.0006648328,0.001461326,0.001717069,0.0007682428,0.00104831,0.001286218,0.003097685,0.01096936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007612148,"about_ca_system_score_gemma":0.001726431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002098662,"about_ca_topic_score_gemma":0.007478103,"domain_scores_codex":[0.9960843,0.0007377226,0.0006831016,0.0006593151,0.001554146,0.0002813621],"domain_scores_gemma":[0.9977616,0.0005681883,0.0002269516,0.0005602448,0.0007126393,0.0001704646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003165338,0.0004151689,0.0009978723,0.001263085,0.00007388059,0.0005444303,0.0002323461,0.0004048763,0.9710469,0.002283697,0.00609333,0.01632797],"study_design_scores_gemma":[0.00008013651,0.002672476,0.007380125,0.0005864688,0.0004170339,0.002259824,0.0001827249,0.002888009,0.8402835,0.001042909,0.142084,0.0001228411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1372001,0.05164396,0.6293808,0.0022048,0.005932348,0.009002437,0.04992855,0.009902596,0.1048046],"genre_scores_gemma":[0.2279838,0.04841181,0.5709624,0.001981622,0.0009300304,0.01539428,0.06584897,0.001024032,0.06746309],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.01283027,"threshold_uncertainty_score":0.04292148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03757502326472646,"score_gpt":0.4550747079628479,"score_spread":0.4174996846981215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}