{"id":"W4206807902","doi":"10.1200/jco.2022.40.4_suppl.008","title":"Nivolumab (NIVO) + 5-fluorouracil/leucovorin/oxaliplatin (mFOLFOX6)/bevacizumab (BEV) versus mFOLFOX6/BEV for first-line (1L) treatment of metastatic colorectal cancer (mCRC): Phase 2 results from CheckMate 9X8.","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Oxaliplatin; Internal medicine; Bevacizumab; Oncology; Nivolumab; Colorectal cancer; Clinical endpoint; Cancer; Randomized controlled trial; Chemotherapy; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001684465,0.0004967204,0.003693059,0.0002295326,0.0003646404,0.00001565844,0.000304867,0.0002413568,0.0007033675],"category_scores_gemma":[0.002504067,0.0003684177,0.001506284,0.0003525011,0.0003113228,0.0001431961,0.0001713806,0.000686874,0.000006840083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002371952,"about_ca_system_score_gemma":0.00271385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001451755,"about_ca_topic_score_gemma":0.003293057,"domain_scores_codex":[0.9930891,0.0005048183,0.004334299,0.0006276779,0.0008520657,0.0005920458],"domain_scores_gemma":[0.9876296,0.006871028,0.003925271,0.0003826842,0.0007230571,0.0004683478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4905436,0.01971203,0.003865706,0.0001007305,0.01095217,0.001560719,0.002436847,0.0008829397,0.0006506561,0.00008265243,0.005679316,0.4635326],"study_design_scores_gemma":[0.3409378,0.3207947,0.01602698,0.0001659833,0.008961464,0.0002504138,0.001915712,0.002278488,0.00244157,0.0005808317,0.3050914,0.0005545766],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795443,0.004782786,0.00007112678,0.006086496,0.00482116,0.001319034,0.002284929,0.00003009036,0.001060082],"genre_scores_gemma":[0.9891967,0.004553024,0.003068808,0.0002597944,0.001519461,0.0003645462,0.0001818212,0.0000602898,0.0007955254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.462978,"threshold_uncertainty_score":0.9998768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2352463132794324,"score_gpt":0.501040987722398,"score_spread":0.2657946744429657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}